LEADER 04450nam 2200529Ia 450 001 9910451817703321 005 20151005070701.0 035 $a(CKB)1000000000450644 035 $a(EBL)3377508 035 $a(SSID)ssj0000260709 035 $a(PQKBManifestationID)11191950 035 $a(PQKBTitleCode)TC0000260709 035 $a(PQKBWorkID)10223919 035 $a(PQKB)11545860 035 $a(OCoLC)567831797 035 $a(MiAaPQ)EBC3377508 035 $a(EXLCZ)991000000000450644 100 $a19860313d1996 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aToxicity of alternatives to chlorofluorocarbons$b[electronic resource] $eHFC-134a and HCFC-123 /$fSubcommittee to Review Toxicity of Alternatives to Chlorofluorocarbons 210 $aWashington, D.C. $cNational Academy Press $cAvailable from [the] Committee on Human Rights$d1996 215 $a1 online resource (130 p.) 300 $aDescription based upon print version of record. 311 $a0-309-57201-0 327 $a""Toxicity of Alternatives to Chlorofluorocarbons: HFC-134a and HCFC-123""; ""Copyright""; ""Preface""; ""Contents""; ""Executive Summary""; ""ASSESSMENT OF MODEL FOR CARDIAC SENSITIZATION""; ""EXPOSURE GUIDANCE LEVELS FOR HFC-134A""; ""EXPOSURE GUIDANCE LEVEL FOR HCFC-123""; ""1 Introduction ""; ""STATEMENT OF TASK""; ""DEFINITIONS""; ""Emergency Exposure Guidance Level""; ""Continuous Exposure Guidance Level""; ""STRUCTURE OF THE REPORT""; ""2 Evaluation of the Dog Cardiac Sensitization Test ""; ""INTRODUCTION""; ""MECHANISM OF ACTION FOR CHEMICALLY INDUCED ARRHYTHMIAS"" 327 $a""PROTOCOL FOR A CARDIAC SENSITIZATION SCREENING STUDY""""CARDIAC SENSITIZATION EXPERIMENTS INVOLVING SELECTED HALOCARBONS""; ""CONCLUSION""; ""REFERENCES""; ""3 Exposure Guidance Levels for Hydrofluorocarbon-134a ""; ""INTRODUCTION""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Acute Toxicity""; ""Cardiac Sensitization""; ""Subacute Toxicity""; ""Subchronic Toxicity""; ""Developmental Toxicity""; ""Reproductive Toxicity""; ""Genotoxicity""; ""Carcinogenicity""; ""SUMMARY"" 327 $a""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""""REFERENCES""; ""4 Exposure Guidance Levels for Hydrochlorofluorocarbon-123 ""; ""INTRODUCTION""; ""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVELS""; ""REFERENCES""; ""Appendix A""; ""SUPPORTING DOCUMENTATION FOR THE EXPOSURE GUIDANCE LEVELS FOR HYDROCHLOROFLUOROCARBON-123""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""TOXICOKINETICS""; ""TOXICITY INFORMATION""; ""Effects in Humans""; ""Effects in Animals""; ""Single-Exposure Studies""; ""Repeat-Exposure Studies""; ""EXPOSURE ASSESSMENT"" 327 $a""RECOMMENDATIONS FOR EXPOSURE GUIDANCE LEVEL""""REFERENCES""; ""ATTACHMENT 1 MATERIAL SAFETY DATA SHEET""; ""ATTACHMENT 2 HALOTHANE""; ""BACKGROUND INFORMATION""; ""Physical and Chemical Properties""; ""Occurrence and Use""; ""ACUTE TOXICITY INFORMATION""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Effects in Humans""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""DISCUSSION""; ""HCFC-123 AND Halothane Comparison""; ""Acute Toxicity and CNS Depression""; ""Cardiac Sensitization""; ""Malignant Hyperthermia""; ""Hepatotoxicity""; ""REFERENCES"" 327 $a""ATTACHMENT 3 SUMMARY OF TOXICITY STUDIES OF HCFC-123""""I. ANIMAL STUDIES: SINGLE EXPOSURE""; ""II. ANIMAL STUDIES: REPEAT EXPOSURE""; ""III. REFERENCES""; ""ATTACHMENT 4 SUMMARY OF ACUTE PHARMACOKINETIC STUDY OF HCFC-123 IN DOGS BY INHALATION""; ""OBJECTIVE""; ""MATERIALS AND METHODS""; ""Exposure System""; ""Blood and Tissue Sampling""; ""Analysis of Blood and Tissue Samples""; ""RESULTS""; ""DISCUSSION"" 606 $aAir$xPollution 606 $aChlorofluorocarbons$xEnvironmental aspects 608 $aElectronic books. 615 0$aAir$xPollution. 615 0$aChlorofluorocarbons$xEnvironmental aspects. 676 $a547.01046 712 02$aNational Academy of Sciences (U.S.).$bSubcommittee to Review Toxicity of Alternatives to Chlorofluorocarbons. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451817703321 996 $aToxicity of alternatives to chlorofluorocarbons$91987065 997 $aUNINA