LEADER 03963nam 22006254a 450 001 9910451785903321 005 20200520144314.0 010 $a1-281-73045-9 010 $a9786611730451 010 $a0-300-12966-1 024 7 $a10.12987/9780300129663 035 $a(CKB)1000000000471991 035 $a(StDuBDS)BDZ0022171458 035 $a(SSID)ssj0000201499 035 $a(PQKBManifestationID)11184383 035 $a(PQKBTitleCode)TC0000201499 035 $a(PQKBWorkID)10245497 035 $a(PQKB)11781868 035 $a(StDuBDS)EDZ0000158001 035 $a(MiAaPQ)EBC3420064 035 $a(DE-B1597)485546 035 $a(OCoLC)1024032087 035 $a(DE-B1597)9780300129663 035 $a(Au-PeEL)EBL3420064 035 $a(CaPaEBR)ebr10170754 035 $a(OCoLC)923589373 035 $a(EXLCZ)991000000000471991 100 $a20010123d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMeselson, Stahl, and the replication of DNA$b[electronic resource] $ea history of "the most beautiful experiment in biology" /$fFrederic Lawrence Holmes 210 $aNew Haven, CT $cYale University Press$d2001 215 $a1 online resource (1 online resource (xii, 503 p.) ) $cill 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-300-08540-0 320 $aIncludes bibliographical references (p. [449]-496) and index. 327 $aMachine generated contents note: Chapter One The Replication Problem 11 -- Chapter Two Meselson and Stahl 49 -- Chapter Three Twists and Turs 75 -- Chapter Four Crossing Fields: Chemical Bonds to Biological Mutants 116 -- Chapter Five Dense Solutions 157 -- Chapter Six The Big Machine 183 -- Chapter Seven Working at High Speed 215 -- Chapter Eight The Unseen Band 272 -- Chapter Nine One Discovery, Three Stories 303 -- Chapter Ten An Extremely Beautiful Experiment 319 -- Chapter Eleven Centrifugal Forces 352 -- Chapter Twelve The Subunits of Semiconservative Replication 388 -- Chapter Thirteen Images of an Experiment 412 -- Chapter Fourteen Afterword 435. 330 $aIn 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment. 606 $aDNA replication$xExperiments$xHistory 606 $aMolecular biology$xExperiments$xHistory 608 $aElectronic books. 615 0$aDNA replication$xExperiments$xHistory. 615 0$aMolecular biology$xExperiments$xHistory. 676 $a572.8/6 700 $aHolmes$b Frederic Lawrence$0726772 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451785903321 996 $aMeselson, Stahl, and the replication of DNA$92440886 997 $aUNINA