LEADER 03963nam 22006254a 450 001 9910451785903321 005 20200520144314.0 010 $a1-281-73045-9 010 $a9786611730451 010 $a0-300-12966-1 024 7 $a10.12987/9780300129663 035 $a(CKB)1000000000471991 035 $a(StDuBDS)BDZ0022171458 035 $a(SSID)ssj0000201499 035 $a(PQKBManifestationID)11184383 035 $a(PQKBTitleCode)TC0000201499 035 $a(PQKBWorkID)10245497 035 $a(PQKB)11781868 035 $a(StDuBDS)EDZ0000158001 035 $a(MiAaPQ)EBC3420064 035 $a(DE-B1597)485546 035 $a(OCoLC)1024032087 035 $a(DE-B1597)9780300129663 035 $a(Au-PeEL)EBL3420064 035 $a(CaPaEBR)ebr10170754 035 $a(OCoLC)923589373 035 $a(EXLCZ)991000000000471991 100 $a20010123d2001 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMeselson, Stahl, and the replication of DNA$b[electronic resource] $ea history of "the most beautiful experiment in biology" /$fFrederic Lawrence Holmes 210 $aNew Haven, CT $cYale University Press$d2001 215 $a1 online resource (1 online resource (xii, 503 p.) ) $cill 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a0-300-08540-0 320 $aIncludes bibliographical references (p. [449]-496) and index. 327 $aMachine generated contents note: Chapter One The Replication Problem 11 -- Chapter Two Meselson and Stahl 49 -- Chapter Three Twists and Turs 75 -- Chapter Four Crossing Fields: Chemical Bonds to Biological Mutants 116 -- Chapter Five Dense Solutions 157 -- Chapter Six The Big Machine 183 -- Chapter Seven Working at High Speed 215 -- Chapter Eight The Unseen Band 272 -- Chapter Nine One Discovery, Three Stories 303 -- Chapter Ten An Extremely Beautiful Experiment 319 -- Chapter Eleven Centrifugal Forces 352 -- Chapter Twelve The Subunits of Semiconservative Replication 388 -- Chapter Thirteen Images of an Experiment 412 -- Chapter Fourteen Afterword 435. 330 $aIn 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a "most beautiful" experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl's quest.This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and serendipitous windfalls, as well as its frustrations, unexpected diversions away from original plans, and chronic uncertainty. Holmes uses research logs, experimental films, correspondence, and interviews with the participants to record the history of Meselson and Stahl's research, from their first thinking about the problem through the publication of their dramatic results. Holmes also reviews the scientific community's reception of the experiment, the experiment's influence on later investigations, and the reasons for its reputation as an exceptionally beautiful experiment. 606 $aDNA replication$xExperiments$xHistory 606 $aMolecular biology$xExperiments$xHistory 608 $aElectronic books. 615 0$aDNA replication$xExperiments$xHistory. 615 0$aMolecular biology$xExperiments$xHistory. 676 $a572.8/6 700 $aHolmes$b Frederic Lawrence$0726772 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451785903321 996 $aMeselson, Stahl, and the replication of DNA$92440886 997 $aUNINA LEADER 05683nam 22008055 450 001 996466226603316 005 20200706115226.0 010 $a1-280-30768-4 010 $a9786610307685 010 $a3-540-24773-4 024 7 $a10.1007/b98118 035 $a(CKB)1000000000212413 035 $a(DE-He213)978-3-540-24773-9 035 $a(SSID)ssj0000096289 035 $a(PQKBManifestationID)11127840 035 $a(PQKBTitleCode)TC0000096289 035 $a(PQKBWorkID)10081562 035 $a(PQKB)10660374 035 $a(MiAaPQ)EBC3088502 035 $a(PPN)155163779 035 $a(EXLCZ)991000000000212413 100 $a20121227d2004 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAbstract State Machines 2004. Advances in Theory and Practice$b[electronic resource] $e11th International Workshop, ASM 2004, Lutherstadt Wittenberg, Germany, May 24-28, 2004. Proceedings /$fedited by Wolf Zimmermann, Bernhard Thalheim 205 $a1st ed. 2004. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2004. 215 $a1 online resource (XII, 240 p.) 225 1 $aLecture Notes in Computer Science,$x0302-9743 ;$v3052 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a3-540-22094-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aInvited Papers -- Intra-step Interaction -- Closed-Loop Modeling and Related Problems of Embedded Control Systems in Engineering -- An ALGOL-View on Turbo ASM -- An ASM Specification of C# Threads and the .NET Memory Model -- Finite Cursor Machines in Database Query Processing -- Research Papers -- Formalizing Liveness-Enriched Sequence Diagrams Using ASMs -- Specification and Validation of the Business Process Execution Language for Web Services -- Monodic ASMs and Temporal Verification -- Towards an Interchange Language for ASMs -- Specification and Implementation Problems for C# -- An ASM Semantics for SSA Intermediate Representations -- Observations on the Decidability of Transitions -- A Security Logic for Abstract State Machines -- Slicing Abstract State Machines -- The Cryptographic Abstract Machine -- Modeling Discretely Timed Systems Using Different Magnitudes of Non-standard Reals. 330 $aAbstract state machines (ASM) sharpen the Church-Turing thesis by the c- sideration of bounded resources for computing devices. They view computations as an evolution of a state. It has been shown that all known models of com- tation can be expressed through speci?c abstract state machines. These models can be given in a representation-independent way. That is one advantage of transferring these models to ASM. The main advantage is, however, to provide a unifying theory to all of these models. At the same time ASM can be re?ned to other ASMs. Stepwise re?nement supports separation of concern during so- ware development and will support component-based construction of systems thus providing a foundation of new computational paradigms such as industrial programming, programming-in-the-large, and programming-in-the-world. ASM 2004 continued the success story of the ASM workshops. Previous workshops were held in the following European cities: Taormina, Italy (2003); Dagstuhl, Germany (2002); Las Palmas de Gran Canaria, Spain (2001); Monte Verita, Switherland (2000); Toulouse, France (1999); Magdeburg, Germany (1998); Cannes, France (1998, 1997); Paderborn, Germany (1996); and H- burg, Germany (1994). The ASM workshops have had predecessors, e.g., the famous Lipari Summer School in 1993, whose in?uential outcome was the f- damental Lipari Guide. 410 0$aLecture Notes in Computer Science,$x0302-9743 ;$v3052 606 $aComputer logic 606 $aMathematical logic 606 $aComputers 606 $aSoftware engineering 606 $aProgramming languages (Electronic computers) 606 $aLogics and Meanings of Programs$3https://scigraph.springernature.com/ontologies/product-market-codes/I1603X 606 $aMathematical Logic and Foundations$3https://scigraph.springernature.com/ontologies/product-market-codes/M24005 606 $aTheory of Computation$3https://scigraph.springernature.com/ontologies/product-market-codes/I16005 606 $aSoftware Engineering$3https://scigraph.springernature.com/ontologies/product-market-codes/I14029 606 $aMathematical Logic and Formal Languages$3https://scigraph.springernature.com/ontologies/product-market-codes/I16048 606 $aProgramming Languages, Compilers, Interpreters$3https://scigraph.springernature.com/ontologies/product-market-codes/I14037 615 0$aComputer logic. 615 0$aMathematical logic. 615 0$aComputers. 615 0$aSoftware engineering. 615 0$aProgramming languages (Electronic computers). 615 14$aLogics and Meanings of Programs. 615 24$aMathematical Logic and Foundations. 615 24$aTheory of Computation. 615 24$aSoftware Engineering. 615 24$aMathematical Logic and Formal Languages. 615 24$aProgramming Languages, Compilers, Interpreters. 676 $a511.3 702 $aZimmermann$b Wolf$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aThalheim$b Bernhard$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a996466226603316 996 $aAbstract State Machines 2004. Advances in Theory and Practice$92179801 997 $aUNISA