LEADER 04758nam 22006734a 450 001 9910451688703321 005 20200520144314.0 010 $a1-281-86256-8 010 $a9786611862565 010 $a3-7643-8552-9 024 7 $a10.1007/978-3-7643-8552-1 035 $a(CKB)1000000000491476 035 $a(EBL)364338 035 $a(OCoLC)288473605 035 $a(SSID)ssj0000290243 035 $a(PQKBManifestationID)11234193 035 $a(PQKBTitleCode)TC0000290243 035 $a(PQKBWorkID)10409436 035 $a(PQKB)11253366 035 $a(DE-He213)978-3-7643-8552-1 035 $a(MiAaPQ)EBC364338 035 $a(PPN)128126450 035 $a(Au-PeEL)EBL364338 035 $a(CaPaEBR)ebr10245932 035 $a(CaONFJC)MIL186256 035 $a(EXLCZ)991000000000491476 100 $a20080124d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBone morphogenetic proteins$b[electronic resource] $efrom local to systemic therapeutics /$fSlobodan Vukicevic, Kuber T. Sampath, editors 205 $a1st ed. 2008. 210 $aBasel ;$aBoston $cBirkha?user$dc2008 215 $a1 online resource (348 p.) 225 1 $aProgress in inflammation research 300 $aDescription based upon print version of record. 311 $a3-7643-8551-0 320 $aIncludes bibliographical references and index. 327 $aDevelopment of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results -- Use of recombinant human BMP-2 in orthopedic trauma -- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects -- Clinical outcomes using rhBMP-2 in spinal fusion applications -- Bone morphogenetic protein signaling is fine-tuned on multiple levels -- Dissection of bone morphogenetic protein signaling using genome-engineering tools -- Alterations of BMP signaling pathway(s) in skeletal diseases -- Signaling cross-talk by bone morphogenetic proteins -- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development -- The role of bone morphogenetic protein 4 (BMP-4) in tooth development -- Bone morphogenetic protein antagonists and kidney -- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins -- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation -- Bone morphogenetic proteins in cartilage biology -- Systemic administration of bone morphogenetic proteins. 330 $aTissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs. In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone. This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies. 410 0$aPIR (Series) 606 $aBone morphogenetic proteins 606 $aBone morphogenetic proteins$xTherapeutic use 608 $aElectronic books. 615 0$aBone morphogenetic proteins. 615 0$aBone morphogenetic proteins$xTherapeutic use. 676 $a612.75 676 $a616.7/1061 701 $aVukicevic$b Slobodan$f1951-$01039570 701 $aSampath$b Kuber T$01039571 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451688703321 996 $aBone morphogenetic proteins$92461873 997 $aUNINA