LEADER 04745nam 2200721Ia 450 001 9910451508703321 005 20200520144314.0 010 $a1-281-86247-9 010 $a9786611862473 010 $a3-540-79462-X 024 7 $a10.1007/978-3-540-79462-2 035 $a(CKB)1000000000492478 035 $a(EBL)367560 035 $a(OCoLC)808727302 035 $a(SSID)ssj0000253275 035 $a(PQKBManifestationID)11206983 035 $a(PQKBTitleCode)TC0000253275 035 $a(PQKBWorkID)10187329 035 $a(PQKB)11618087 035 $a(DE-He213)978-3-540-79462-2 035 $a(MiAaPQ)EBC367560 035 $a(PPN)127055770 035 $a(Au-PeEL)EBL367560 035 $a(CaPaEBR)ebr10245882 035 $a(CaONFJC)MIL186247 035 $a(EXLCZ)991000000000492478 100 $a20081029d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe subthalamic nucleus$hPart 2$iModelling and simulation of activity$b[electronic resource] /$fTjitske Heida, Enrico Marani, and Kamen G. Usunoff 205 $a1st ed. 2008. 210 $aBerlin $cSpringer$dc2008 215 $a1 online resource (101 pages) 225 1 $aAdvances in anatomy, embryology, and cell biology ;$v199 300 $aDescription based upon print version of record. 311 $a3-540-79461-1 320 $aIncludes bibliographical references and index. 327 $aThe Basal Ganglia -- STN Activity Recorded in Vitro: Brain Slices -- STN Activity Recorded in Vitro: Dissociated Cell Cultures -- STN Cell Models and Simulation of Neuronal Networks -- Comparison of Part I and Part II. 330 $aThis monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson?s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results. 410 0$aAdvances in anatomy, embryology, and cell biology ;$vv. 199. 606 $aSubthalamus 606 $aSubthalamus$xCytology 606 $aBasal ganglia 606 $aNeural networks (Neurobiology) 608 $aElectronic books. 615 0$aSubthalamus. 615 0$aSubthalamus$xCytology. 615 0$aBasal ganglia. 615 0$aNeural networks (Neurobiology) 676 $a573.86 700 $aHeida$b T$g(Tjitske),$f1972-$0903944 701 $aMarani$b Enrico$0903945 701 $aUsunoff$b K. G$g(Kamen G.),$f1941-$0903946 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451508703321 996 $aThe subthalamic nucleus$92020820 997 $aUNINA