LEADER 04528nam 2200673Ia 450 001 9910451507803321 005 20200520144314.0 010 $a1-281-86246-0 010 $a9786611862466 010 $a3-540-79460-3 024 7 $a10.1007/978-3-540-79460-8 035 $a(CKB)1000000000492477 035 $a(EBL)367559 035 $a(OCoLC)780884790 035 $a(SSID)ssj0000253274 035 $a(PQKBManifestationID)11215984 035 $a(PQKBTitleCode)TC0000253274 035 $a(PQKBWorkID)10186519 035 $a(PQKB)10701634 035 $a(DE-He213)978-3-540-79460-8 035 $a(MiAaPQ)EBC367559 035 $a(PPN)127055762 035 $a(Au-PeEL)EBL367559 035 $a(CaPaEBR)ebr10245986 035 $a(CaONFJC)MIL186246 035 $a(EXLCZ)991000000000492477 100 $a20080828d2008 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe subthalamic nucleus$hPart 1$iDevelopment, cytology, topography, and connections$b[electronic resource] /$fEnrico Marani ... [et al.] 205 $a1st ed. 2008. 210 $aBerlin $cSpringer$dc2008 215 $a1 online resource (129 p.) 225 1 $aAdvances in anatomy, embryology, and cell biology ;$vv. 198 300 $aDescription based upon print version of record. 311 $a3-540-79459-X 320 $aIncludes bibliographical references and index. 327 $aCytology of the Subthalamic Nucleus -- Ontogeny of the Subthalamic Nucleus -- Topography of the Rat, Cat, Baboon and Human Subthalamic Nucleus -- Connections of the Subthalamic Nucleus -- Nigro-Subthalamic Connections in the Rat. 330 $aThis monograph gives an overview of the STN. It treats the position of the STN in hemiballism, based on older and recent data. The cytology encompasses the neuronal types present in the STN in nearly all studied species and focuses on interneurons and the extent of their dendrites. Ultrastructural features are described for cat and baboon (F1, F2, Sr, LR1, LR2 boutons and d.c.v. terminals, together with vesicle containing dendrites), the cytochemistry is focused on receptors (dopamine, cannabinoid, opioid, glutamate, GABA, serotonin, and cholinergic-, purinergic ones) and calcium binding proteins and calcium channels. The development of the subthalamic nucleus from the subthalamic cell cord is given together with its developing connections. The topography of rat, cat, baboon and man is worked out as to cytology, sagittal borders, surrounding nuclei and tracts, and aging of the human STN. The connections of the STN are extensively elaborated on: cortical-, subthalamo-cortical-, pallidosubthalamic-, pedunculopontine-, raphe-, thalamic-, central grey-, and nigral connections. Emphasis is put on human connections. Recent nigro-subthalamic studies showed a contralateral projection. The role of the STN in the basal ganglia circuitry is described as to the direct, indirect and hyperdirect pathway. The change the STN undergoes in Parkinson?s disease in neuronal firing rate and firing pattern is demonstrated together with the possible mechanisms of deep brain stimulation. The results of in vitro measurements on dissociated cultured subthalamic neurons are presented. The preliminary effects of application of acetylcholine and high frequency stimulation are described. This part is preceded with studies concerning spontaneous activity, depolarizing and hyperpolarizing inputs, synaptic inputs, high frequency stimulation, and burst activity of STN cells. The last extensive part concerns STN cell models and simulation of neuronal networks. Single cell models (model of Otsuka and Terman/Rubin) are compared and the multi-compartment model of Gillies and Willshaw is explored. The globus pallidus externus-STN network as proposed by Terman is briefly described. The monograph finishes with a series of interpretations of the results. 410 0$aAdvances in anatomy, embryology, and cell biology ;$vv. 198. 606 $aSubthalamus 606 $aSubthalamus$xCytology 606 $aSubthalamus$xDevelopment 608 $aElectronic books. 615 0$aSubthalamus. 615 0$aSubthalamus$xCytology. 615 0$aSubthalamus$xDevelopment. 676 $a573.86 700 $aMarani$b Enrico$0903945 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451507803321 996 $aThe subthalamic nucleus$92177882 997 $aUNINA