LEADER 05508nam 2200685Ia 450 001 9910451313403321 005 20200520144314.0 010 $a1-281-86697-0 010 $a9786611866976 010 $a1-86094-717-4 035 $a(CKB)1000000000406993 035 $a(EBL)1214961 035 $a(SSID)ssj0000199333 035 $a(PQKBManifestationID)12027869 035 $a(PQKBTitleCode)TC0000199333 035 $a(PQKBWorkID)10184501 035 $a(PQKB)10649608 035 $a(MiAaPQ)EBC1214961 035 $a(WSP)00000048 035 $a(Au-PeEL)EBL1214961 035 $a(CaPaEBR)ebr10713364 035 $a(CaONFJC)MIL186697 035 $a(OCoLC)815741996 035 $a(EXLCZ)991000000000406993 100 $a20051124d2005 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMatrix metalloproteinases in the central nervous system$b[electronic resource] /$feditors, Katherine Conant, Paul E. Gottschall 210 $aLondon $cImperial College Press ;$aHackensack, NJ $cDistributed by World Scientific$dc2005 215 $a1 online resource (346 p.) 300 $aDescription based upon print version of record. 311 $a1-86094-559-7 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Foreword; I. A Brief Overview; Chapter 1. The Matrix Metalloproteinases and Their Inhibitors Madeleine M. Handsley, Janet Cross, Jelena Gavrilovic, and Dylan R. Edwards; 1. Introduction; 2. The MMP Family; 3. Regulation of MMP Activity; 4. Endogenous Inhibitors of Metalloproteinases; 5. Novel Roles for MMPs; 6. ECM Targets in the CNS; 7. Generation of Matricryptic Sites in ECM Components; 8. Growth Factor Liberation from ECM "Stores"; 9. Chemokine Gradient Generation; 10. Blood-Brain Barrier Substrates for MMPs; 11. Conclusion; References; II. Regulation of MMP Expression 327 $aChapter 2. Genetic Regulation of the Matrix Metalloproteinases and Related Proteins Tammie Roy and Elizabeth A. Milward1. Introduction; 2. Stimuli Triggering Alterations in MMP Gene Expression; 3. Alterations in Other MMPs; 4. Neurotransmitters; 5. Cell-Cell and Cell-Matrix Interactions; 6. Physical and Biochemical Stress; 7. Suppressive Factors; 8. Feedback Control; 9. Signalling Cascades Involved in Regulating MMP Gene Expression; 9.1. The MAPK pathway; 9.2. The NF-?B pathway; 9.3. The 'JAK/STAT' pathway; 9.4. The PI3K/Akt system; 9.5. The Smad pathway 327 $a9.6. Cross-talk and competition between pathways9.7. Pathways operating in the nervous system; 10. Genetic Elements Regulating MMP Gene Expression; 10.1. Constitutive and inducible transcription factors; 10.2. Orchestrating multigene responses; 10.3. AP-1 binding sites and related elements; 10.4. Other promoter elements; 10.5. Chromatin remodelling; 11. Regulation of the MMP-2, MMP-11 and MMP-14 (MT1-MMP) Genes; 11.1. The MMP-2 gene; 11.2. The MMP-11 gene; 11.3. The MMP-14 gene; 12. Regulation of ADAMs Family Gene Expression; 13. Regulation of TIMP Gene Expression 327 $a14. Inverse Regulation of MMPs and TIMPs15. Regulation of TIMPs Independent of MMP Inhibitory Functions; 16. Post-Transcriptional Regulation of MMP Expression; 17. Regulation of MMP Gene Expression in the Healthy Nervous System; 18. Neuronal Expression; 19. Astrocyte Expression; 20. Microglial Expression; 21. Endothelial and Other Cells; 22. Oligodendrocyte and Schwann Cell Expression; 23. Expression of TIMPs in the Nervous System; 24. Expression in Nervous System Development and Plasticity; 25. MMP Gene Regulation in Nervous System Injury and Disease 327 $a26. Regulation in Nervous System Malignancies27. Regulation in Nervous System Injury; 28. Genetic Polymorphisms and MMP Expression; 29. Conclusion; References; Chapter 3. Post-Translational Modification Zezong Gu, Marcus Kaul, and Stuart A. Lipton; 1. Introduction; 2. Cysteine Switch Mechanism; 3. Modification of MMPs by S-Nitrosylation; 4. S-Nitrosylation Leads to MMP-9 Activation In Vitro; 5. NO-Induced Subsequent Oxidation; 6. Peptide Mass Fingerprinting Analysis of Cysteine Residue Post-Translational Modifications; 7. Structural Model of S-Nitrosylation of MMPs 327 $a8. MMPs in Neurological Diseases 330 $aThis book presents the reader with an understanding of the role played by matrix metalloproteinases (MMPs) in the normal and diseased central nervous system (CNS). These enzymes may be important to brain development, and may also contribute to tissue destruction, which is observed with inflammatory and degenerative conditions of the brain. The book provides a background on the biology of MMPs, and on the stimuli and conditions that are linked to an increase in their production and activity. It describes the targets of MMPs, which include matrix proteins such as collagen, soluble cytokines and 606 $aMetalloproteinases 606 $aCentral nervous system 606 $aExtracellular matrix proteins 608 $aElectronic books. 615 0$aMetalloproteinases. 615 0$aCentral nervous system. 615 0$aExtracellular matrix proteins. 676 $a612.8 701 $aConant$b Katherine$0986289 701 $aGottschall$b Paul E$0986290 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910451313403321 996 $aMatrix metalloproteinases in the central nervous system$92254214 997 $aUNINA