LEADER 05210nam 22006854a 450 001 9910450813603321 005 20200520144314.0 010 $a981-277-687-7 035 $a(CKB)1000000000412829 035 $a(EBL)1679423 035 $a(OCoLC)879023613 035 $a(SSID)ssj0000263456 035 $a(PQKBManifestationID)11205164 035 $a(PQKBTitleCode)TC0000263456 035 $a(PQKBWorkID)10273436 035 $a(PQKB)11053891 035 $a(MiAaPQ)EBC1679423 035 $a(WSP)00005051 035 $a(Au-PeEL)EBL1679423 035 $a(CaPaEBR)ebr10201159 035 $a(CaONFJC)MIL505390 035 $a(EXLCZ)991000000000412829 100 $a20030613d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 04$aThe ubiquitin-proteasome proteolytic system$b[electronic resource] $efrom classical biochemistry to human diseases /$feditors, Aaron J. Ciechanover, Maria G. Masucci 210 $aNew Jersey $cWorld Scientific$dc2002 215 $a1 online resource (242 p.) 225 1 $aRecent advances in human biology ;$vv. 9 300 $aDescription based upon print version of record. 311 $a981-238-100-7 320 $aIncludes bibliographical references. 327 $aContents ; Preface ; The Ubiquitin System and Some of Its Roles in Cell Cycle Control ; References ; The Ubiquitin System and the N-End Rule Pathway ; Summary ; The Ubiquitin System ; The N-End Rule Pathway ; Physical Association of Ubiquitin Ligases and the 26S Proteasome 327 $aPeptide Import and the N-End Rule Pathway The N-End Rule Pathway and Fidelity of Chromosome Segregation ; Concluding Remarks ; References ; Phosphorylation-Dependent Substrate Recognition in Ubiquitin-Mediated Proteolysis ; Abstract 327 $aModular Protein Interaction Domains Regulate Dynamic Cellular Behaviour Protein-Protein Interactions Determine Specificity in Ubiquitin-Mediated Proteolysis ; Cdk Activity and the Control of DNA Replication ; Discovery of SCF Ubiquitin Ligases 327 $aPhosphorylation-Dependent Substrate Recognition by SCF Complexes Conservation of SCF Function in the Cell Cycle ; The Cdc4 Phospho-Degron ; Multi-Site Phosphorylation and Ultrasensitivity ; The Sicl-Cdc4 Interaction: Theoretical Considerations ; Discussion ; Prospects ; References 327 $aThe 26S Proteasome: A Supramolecular Assembly Designed for Controlled Proteolysis Introduction ; Structural Features of the 26S Proteasome ; Conclusions ; References ; Mechanisms and Regulation of Ubiquitin-Mediated Limited Processing of the NF-kBa Precursor Protein p105 ; Summary 327 $aIntroduction 330 $a Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory. This book tells the story of the ubiquitin system as we currently know it: from the regulatio 410 0$aRecent advances in human biology ;$vv. 9. 606 $aUbiquitin 606 $aProteolytic enzymes 606 $aProteins$xMetabolism 608 $aElectronic books. 615 0$aUbiquitin. 615 0$aProteolytic enzymes. 615 0$aProteins$xMetabolism. 676 $a612/.01575 701 $aCiechanover$b Aaron J$0867091 701 $aMasucci$b Maria G$0949912 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910450813603321 996 $aThe ubiquitin-proteasome proteolytic system$92147213 997 $aUNINA