LEADER 03382nam 22006852 450 001 9910450497003321 005 20151005020623.0 010 $a1-107-13017-4 010 $a1-280-16041-1 010 $a9786610160419 010 $a0-511-06321-0 010 $a0-511-11922-4 010 $a1-139-14694-7 010 $a0-511-05688-5 010 $a0-511-32267-4 010 $a0-511-54177-5 010 $a0-511-07167-1 035 $a(CKB)1000000000018014 035 $a(EBL)217773 035 $a(OCoLC)57417979 035 $a(SSID)ssj0000140418 035 $a(PQKBManifestationID)11149587 035 $a(PQKBTitleCode)TC0000140418 035 $a(PQKBWorkID)10029822 035 $a(PQKB)11778684 035 $a(UkCbUP)CR9780511541773 035 $a(MiAaPQ)EBC217773 035 $a(Au-PeEL)EBL217773 035 $a(CaPaEBR)ebr10069815 035 $a(CaONFJC)MIL16041 035 $a(EXLCZ)991000000000018014 100 $a20090501d2002|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDNA microarrays and gene expression /$fPierre Baldi and G. Wesley Hatfield$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2002. 215 $a1 online resource (xvi, 213 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-17635-2 311 $a0-521-80022-6 320 $aIncludes bibliographical references and index. 327 $aCover; Half-title; Title; Copyright; Contents; Preface; 1 A brief history of genomics; 2 DNA array formats; 3 DNA array readout methods; 4 Gene expression profiling experiments: Problems, pitfalls, and solutions; 5 Statistical analysis of array data: Inferring changes; 6 Statistical analysis of array data: Dimensionality reduction,clustering,and regulatory regions; 7 The design, analysis,and interpretation of gene expression profiling experiments; 8 Systems biology; Appendix A; Appendix B; Appendix C; Appendix D; Index 330 $aMassive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology. 517 3 $aDNA Microarrays & Gene Expression 606 $aDNA microarrays 606 $aGene expression 615 0$aDNA microarrays. 615 0$aGene expression. 676 $a572.8/65 700 $aBaldi$b Pierre$0282482 702 $aHatfield$b G. Wesley$f1940- 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910450497003321 996 $aDNA microarrays and gene expression$92480548 997 $aUNINA