LEADER 03640nam 22006732 450 001 9910450404803321 005 20151005020622.0 010 $a1-107-12776-9 010 $a1-280-41736-6 010 $a9786610417360 010 $a1-139-14566-5 010 $a0-511-18051-9 010 $a0-511-06598-1 010 $a0-511-05967-1 010 $a0-511-30742-X 010 $a0-511-54644-0 010 $a0-511-06811-5 035 $a(CKB)1000000000017937 035 $a(EBL)217832 035 $a(OCoLC)228111013 035 $a(SSID)ssj0000120648 035 $a(PQKBManifestationID)11145893 035 $a(PQKBTitleCode)TC0000120648 035 $a(PQKBWorkID)10092557 035 $a(PQKB)10522231 035 $a(UkCbUP)CR9780511546440 035 $a(MiAaPQ)EBC217832 035 $a(Au-PeEL)EBL217832 035 $a(CaPaEBR)ebr10069982 035 $a(CaONFJC)MIL41736 035 $a(EXLCZ)991000000000017937 100 $a20090508d2002|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aChemotherapeutic targets in parasites $econtemporary strategies /$fTag E. Mansour ; with the assistance of Joan MacKinnon Mansour$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2002. 215 $a1 online resource (xiv, 226 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-01836-6 311 $a0-521-62065-1 320 $aIncludes bibliographical references and index. 327 $aCover; Half-title; Title; Copyright; Contents; Preface; Acknowledgments; 1 The Search for Antiparasitic Agents; 2 Biophysical, Genomic, and Proteomic Analysis of Drug Targets; 3 Energy Metabolism in Parasitic Helminths; 4 Antimalarial Agents and Their Targets; 5 Antitrypanosomal and Antileishmanial Targets; 6 Targets in Amitochondrial Protists; 7 Neuromuscular Structures and Microtubules as Targets; 8 Targets in the Tegument of Flatworms; Epilogue; Index 330 $aParasitic infections are the most prevalent of human diseases, and researchers continue to face the challenge of designing drugs to successfully counteract them. Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets in malaria, trypanosomes, leishmania and amitochondrial protists. Chapters on helminths include metabolic, neuromuscular, microtubular and tegumental targets. Emphasized throughout is the design of more selective and less toxic drugs than in the past. This book will be especially relevant to medical and clinical researchers and to graduate students in parasitology, pharmacology, medicine, microbiology, and biochemistry. 606 $aAntiparasitic agents 606 $aParasitic diseases$xChemotherapy 615 0$aAntiparasitic agents. 615 0$aParasitic diseases$xChemotherapy. 676 $a616.9/6061 700 $aMansour$b Tag E.$01047680 702 $aMansour$b Joan MacKinnon 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910450404803321 996 $aChemotherapeutic targets in parasites$92475413 997 $aUNINA