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010   $a9786610504855
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100   $a20050805d2005      uy             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aFree radicals and diseases$b[electronic resource] $egene expression, cellular metabolism and pathophysiology /$fedited by Tilman Grune
210   $aAmsterdam ;$aOxford $cIOS Press$dc2005
215   $a1 online resource (204 p.)
225 1 $aNATO science series. Series I, Life and behavioural sciences,$x1566-7693 ;$vv. 367
300   $aDescription based upon print version of record.
311   $a1-58603-518-5 
320   $aIncludes bibliographical references and index.
327   $aTitle page; Preface; Contents; DNA Lesions as Biomarkers of Inflammation and Oxidative Stress: A Preliminary Evaluation; Lipid Peroxidation Measurements - Methodological Approaches and Clinical Importance; Role of Oxidative Stress in Aging of the Yeast Saccharomyces cerevisiae; mtNOS: Regulation by Mitochondrial Membrane Potential; Mutliplicity of Mitochondrial Functioning; ROS-Induced Oscillations of Mitochondrial Transmembrane Potential in Cultured Rat Astocytes; The Effects of Nitric Oxide and Peroxynitrite on MnSOD (E. coli)
327   $aThe Proteasomal Degradation System and Its Role During Oxidative StressPeptide Methionine Sulfoxide Reductases in Aging and Oxidative Stress; Activation of Microglial Proteolysis; Vitamin E Metabolism; Significance of the alpha-Tocopherol Salvage Pathway; Induction and Inhibition of Apoptotic Pathways by Hydrogen Peroxide; Photooxidative Processes in Skin: From Damage to Signaling; Role of Cholesterol or Homocysteine in the Development of Atherosclerosis: Effect of Vitamin E; Different Roles of Nitric Oxide in Regulation of Interscapular Brown Adipose Tissue Hyperplasia
327   $aAdaptation to Exercise-Induced Oxidative StressClinical Use of Carotenoids - Antioxidative Protection versus Prooxidative Side Effects; Author Index
330   $aThis publication contains an extensive overview of free radicals and diseases, including both basic science approaches and clinical applications. The research of the last decades has contributed substantially to the understanding role and function of these metabolites. It is the aim of the editors to include a large variety of biological models ranging from yeast over mitochondria, isolated cells and cell culture models to animals and humans. The topics discussed focus on the function and integrity of mitochondria under oxidative conditions, the role of protein oxidation and proteolysis in the
410  0$aNATO science series.$nSeries I,$pLife and behavioural sciences ;$vv. 367.
606   $aFree radicals (Chemistry)$xPathophysiology
606   $aActive oxygen$xPathophysiology
608   $aElectronic books.
615  0$aFree radicals (Chemistry)$xPathophysiology.
615  0$aActive oxygen$xPathophysiology.
676   $a616.07
701   $aGrune$b Tilman$0914277
712 12$aNATO Advanced Study Institute on Free Radicals and Diseases: Gene Expression, Cellular Metabolism and Pathophysiology
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910450367703321
996   $aFree radicals and diseases$92136087
997   $aUNINA