LEADER 03376nam 2200649 a 450 001 9910450162003321 005 20200520144314.0 010 $a1-84755-070-3 010 $a1-60119-027-1 035 $a(CKB)1000000000238269 035 $a(EBL)1185420 035 $a(SSID)ssj0000071754 035 $a(PQKBManifestationID)11107178 035 $a(PQKBTitleCode)TC0000071754 035 $a(PQKBWorkID)10091565 035 $a(PQKB)10393614 035 $a(MiAaPQ)EBC1185420 035 $a(PPN)198475810 035 $a(Au-PeEL)EBL1185420 035 $a(CaPaEBR)ebr10621270 035 $a(CaONFJC)MIL871773 035 $a(OCoLC)843641090 035 $a(EXLCZ)991000000000238269 100 $a20060105d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug design$b[electronic resource] $ecutting edge approaches /$fedited by Darren R. Flower 210 $aCambridge, U.K. $cRoyal Society of Chemistry$dc2002 215 $a1 online resource (204 p.) 225 1 $aSpecial publication ;$vno. 279 300 $a"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso. 311 $a0-85404-816-2 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject Index 330 $aPharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets.Providing details of state-of-the-art research, Drug Design: Cutting Edge Approac 410 0$aSpecial publication (Royal Society of Chemistry (Great Britain)) ;$vno. 279. 606 $aDrugs$xDesign$vCongresses 606 $aDrugs$xDesign$xMathematical models$vCongresses 606 $aArtificial intelligence$xMedical applications$vCongresses 606 $aDrugs$xResearch$xMethodology$vCongresses 608 $aElectronic books. 615 0$aDrugs$xDesign 615 0$aDrugs$xDesign$xMathematical models 615 0$aArtificial intelligence$xMedical applications 615 0$aDrugs$xResearch$xMethodology 676 $a615.19 701 $aFlower$b Darren R$0472707 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910450162003321 996 $aDrug design$92248041 997 $aUNINA LEADER 04337oam 2200649I 450 001 9910791016603321 005 20230814231914.0 010 $a0-429-92333-3 010 $a0-367-32939-5 010 $a0-429-90910-1 010 $a0-429-48433-X 010 $a1-78241-270-0 024 7 $a10.4324/9780429484339 035 $a(CKB)2550000001322512 035 $a(EBL)1721166 035 $a(SSID)ssj0001322059 035 $a(PQKBManifestationID)11814413 035 $a(PQKBTitleCode)TC0001322059 035 $a(PQKBWorkID)11423428 035 $a(PQKB)11474677 035 $a(MiAaPQ)EBC1721166 035 $a(Au-PeEL)EBL1721166 035 $a(CaPaEBR)ebr10889336 035 $a(CaONFJC)MIL621918 035 $a(OCoLC)882609219 035 $a(OCoLC)1029500813 035 $a(EXLCZ)992550000001322512 100 $a20180706d2018 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTraumatised and non-traumatised states of the personality $ea clinical understanding using Bion's approach /$fRafael E. Lo pez-Corvo 210 1$aLondon :$cRoutledge,$d2018. 215 $a1 online resource (363 p.) 300 $aDescription based upon print version of record. 311 $a1-78220-137-8 311 $a1-306-90667-9 320 $aIncludes bibliographical references and index. 327 $aCOVER; CONTENTS; ACKNOWLEDGEMENTS; ABOUT THE AUTHOR; PREFACE; INTRODUCTION Theoretical considerations about pre-conceptual traumas andt raumatised and non-traumatised states of the personality; CHAPTER ONE "Evicted from life": time distortion between pre-conceptual and conceptual traumas; CHAPTER TWO The mark of Cain: ego and superego narcissistic identifications with pre-conceptual traumas; CHAPTER THREE The conceptualisation of pre-conceptual traumas; CHAPTER FOUR The unconscious: the messenger of truth from Bion's perspective of container-contained interaction 327 $aCHAPTER FIVE Transformation of pre-conceptual traumas: heteromorphic or homeomorphic symbolisationsCHAPTER SIX "Deferred action" ("apre?s coup") and the emotional interaction between pre-conceptual and conceptual traumas; CHAPTER SEVEN Pre-conceptual traumas as the tyrannical presence of absences; CHAPTER EIGHT Negative and positive links as a form of communication in the traumatised and non-traumatised states (TS TS); CHAPTER NINE The traumatised ego and the traumatising superego; CHAPTER TEN Acting out pre-conceptual traumas: interruption of therapy and "catastrophic change" 327 $aCHAPTER ELEVEN Pre-conceptual traumas: inflicted by chance and repeated by compulsionCHAPTER TWELVE The world of sigma (?); CHAPTER THIRTEEN The triangle's entrapment: pre-conceptual traumas and the oedipal condition; CHAPTER FOURTEEN All pregnancies are twins: one baby in the uterus and one baby in the mind - pre-conceptual traumas and infertility; CHAPTER FIFTEEN Children from the claustrum: pre-conceptual traumas and addiction; CHAPTER SIXTEEN Pre-conceptual traumas and somatic pathology: the body's attempt to dream a repetitious undreamed dream 327 $aCHAPTER SEVENTEEN Pre-conceptual traumas and totalitarianismNOTES; REFERENCES; INDEX 330 $aThis book offers an original conception of trauma and of the working mind that has not been previously presented. It is mostly based on essentials taken from Bion's contributions. All human beings are fatalistically marked by the presence and eventual disappearance of primary part-objects. Many of these 'presence-absences' are temporary events, but others will overcome Freud's ""protective shield"" and become permanent, amounting to an enduring distress or ""pre-conceptual trauma"". Like the Mad Hatter's teatime in Alice's Adventures in Wonderland, pre-conceptual traumas become an eternal 'now 606 $aPsychic trauma in children$xTreatment 606 $aRefugee children$xMental health 615 0$aPsychic trauma in children$xTreatment. 615 0$aRefugee children$xMental health. 676 $a618.928521 700 $aLópez Corvo$b Rafael E.$0595989 801 0$bFlBoTFG 801 1$bFlBoTFG 906 $aBOOK 912 $a9910791016603321 996 $aTraumatised and non-traumatised states of the personality$93692212 997 $aUNINA