LEADER 03376nam 2200649 a 450 001 9910450162003321 005 20200520144314.0 010 $a1-84755-070-3 010 $a1-60119-027-1 035 $a(CKB)1000000000238269 035 $a(EBL)1185420 035 $a(SSID)ssj0000071754 035 $a(PQKBManifestationID)11107178 035 $a(PQKBTitleCode)TC0000071754 035 $a(PQKBWorkID)10091565 035 $a(PQKB)10393614 035 $a(MiAaPQ)EBC1185420 035 $a(PPN)198475810 035 $a(Au-PeEL)EBL1185420 035 $a(CaPaEBR)ebr10621270 035 $a(CaONFJC)MIL871773 035 $a(OCoLC)843641090 035 $a(EXLCZ)991000000000238269 100 $a20060105d2002 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrug design$b[electronic resource] $ecutting edge approaches /$fedited by Darren R. Flower 210 $aCambridge, U.K. $cRoyal Society of Chemistry$dc2002 215 $a1 online resource (204 p.) 225 1 $aSpecial publication ;$vno. 279 300 $a"Proceedings of the meeting on Cutting Edge Approaches to Drug Design held on 13 March 2001 at the Scientific Societies Lecture Theatre, London, UK"--T.p. verso. 311 $a0-85404-816-2 320 $aIncludes bibliographical references and index. 327 $aCONTENTS; Molecular Informatics: Sharpening Drug Design's Cutting Edge; High-Throughput X-Ray Crystallography for Drug Discovery; Trawling the Genome for G Protein-coupled Receptors: the Importance of Integrating Bioinformatic Approaches; Virtual Screening of Virtual Libraries - an Efficient Strategy for LeadGeneration; Virtual Techniques for Lead Optimisation; The Impact of Physical Organic Chemistry on the Control of Drug-likeProperties; Mutagenesis and Modelling Highlight the Critical Nature of theTM2-loop-TM3 Region of Biogenic Amine GPCRS; Computational Vaccine Design; Subject Index 330 $aPharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of the latest informatics techniques, this book looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, will concentrate on G-protein coupled receptors as potential disease targets.Providing details of state-of-the-art research, Drug Design: Cutting Edge Approac 410 0$aSpecial publication (Royal Society of Chemistry (Great Britain)) ;$vno. 279. 606 $aDrugs$xDesign$vCongresses 606 $aDrugs$xDesign$xMathematical models$vCongresses 606 $aArtificial intelligence$xMedical applications$vCongresses 606 $aDrugs$xResearch$xMethodology$vCongresses 608 $aElectronic books. 615 0$aDrugs$xDesign 615 0$aDrugs$xDesign$xMathematical models 615 0$aArtificial intelligence$xMedical applications 615 0$aDrugs$xResearch$xMethodology 676 $a615.19 701 $aFlower$b Darren R$0472707 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910450162003321 996 $aDrug design$92248041 997 $aUNINA LEADER 02454nam 2200349 450 001 9910725996203321 005 20230624214220.0 035 $a(CKB)5470000002601698 035 $a(NjHacI)995470000002601698 035 $a(EXLCZ)995470000002601698 100 $a20230624d2019 uy 0 101 0 $afre 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aVulne?rables ou dangereux? $eune anthropologie du souci des adolescents difficiles = Vulnerable or dangerous? : an anthropology of care for difficult adolescents /$fYannis Gansel, Richard Rechtman 210 1$aLyon :$cENS E?ditions,$d[2019] 210 4$dİ2019 215 $a1 online resource 330 $aAu cours des anne?es 2000, une se?rie de transformations institutionnelles traversent le champ de l'adolescence : reconnaissance de la notion de handicap psychique, accumulation de re?formes dans le cadre de la justice des mineurs, de?veloppement de dispositifs d'e?coute de la souffrance. C'est dans ce contexte social que se proble?matise la cate?gorie d'" adolescents difficiles ". Il s'agit d'une population de jeunes qui, ne rentrant pas de fac?on suffisamment satisfaisante dans les cases des savoirs et des pratiques du me?dicosocial, de la protection de l'enfance, de la justice ou du sanitaire, " se font rejeter de partout ". Cette population interstitielle devient alors l'objet spe?cifique d'un souci collectif, de savoirs cliniques et d'actions publiques. Dans quelles conditions historiques et sociales l'expertise clinique a-t-elle identifie? ce proble?me? Comment les acteurs de terrain e?prouvent ce souci? Quelles pratiques de?veloppent-ils pour le traiter? A? partir d'une recherche documentaire et d'une enque?te ethnographique de longue dure?e, cet ouvrage apporte une contribution a? l'anthropologie de la sante? mentale en France. Il explore concre?tement ce que la psychiatrisation signifie, dans le champ des adolescents difficiles, aux confins de la dangerosite? et de la vulne?rabilite?, des pratiques de sollicitude et de contrainte. 606 $aChild welfare 615 0$aChild welfare. 676 $a362.7 700 $aGansel$b Yannis$01297960 702 $aRechtman$b Richard 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910725996203321 996 $aVulne?rables ou dangereux$93392954 997 $aUNINA