LEADER 05123nam 22006134a 450 001 9910449881403321 005 20200520144314.0 010 $a1-86094-648-8 035 $a(CKB)1000000000002282 035 $a(EBL)1223625 035 $a(SSID)ssj0000278852 035 $a(PQKBManifestationID)11238042 035 $a(PQKBTitleCode)TC0000278852 035 $a(PQKBWorkID)10259042 035 $a(PQKB)10822787 035 $a(MiAaPQ)EBC1223625 035 $a(WSP)0000P085 035 $a(Au-PeEL)EBL1223625 035 $a(CaPaEBR)ebr5000419 035 $a(CaONFJC)MIL492170 035 $a(OCoLC)854974145 035 $a(EXLCZ)991000000000002282 100 $a20000731d2000 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDrugs and the older population$b[electronic resource] /$feditors, Peter Crome, Gary Ford 210 $aLondon $cImperial College Press ;$aRiver Edge, NJ $cDistributed by World Scientific Pub. Co.$d2000 215 $a1 online resource (728 p.) 300 $aDescription based upon print version of record. 311 $a1-86094-099-4 320 $aIncludes bibliographical references and index. 327 $aForeword; Introduction; List of Contributors; Contents; CHAPTER 1 Pharmacoepidemiology and the Elderly; Introduction; Types of Pharmacoepidemiologic Studies; Adverse and Beneficial Effects of Drug Therapy; Drug Utilization Studies; Antipsychotic Drugs; Thrombolysis in Acute Myocardial Infarction; Opioids for Pain Management in Cancer; Pharmacoeconomic Studies; Quality-of-life Studies; Importance of Postmarketing Drug Surveillance; Principles of Pharmacoepidemiologic Research; The Frequency of Adverse Drug Events; Study Designs; Observational Studies; Ecologic (correlational) Studies 327 $aCross-sectional StudiesCase-control Studies; Cohort Studies; Common Types of Error in Observational Studies; Experimental Studies; Measures of Association; Data Sources for Observational Pharmacoepidemiologic Studies; Future Research Directions; References; CHAPTER 2 Drug Use and Older People: Sociological Perspectives; Introduction; The Role of Biomedicine; Doctors and the Elderly; Social Characteristics and Patterns of Drug Use; Drugs and the Culture of Ageing; Empowering Older People: The Role of Self-health Care and Consumerism; References 327 $aCHAPTER 3 Economic Aspects of Drugs and Older PeopleIntroduction; What is Health Economics?; Demographic Trends; Life Expectancy; Prevalence of Acute and Chronic Ill-Health; GP Consultation Rates; Prescription Items Dispensed; Prescription Costs; Health Economics; Ten Common Mistakes in Health Economics; Methods of Analysis; Costs; Where Costs Fall; The Type of Costs; Outcomes; Sensitivity Analysis; Different Perspective; References; CHAPTER 4 Pharmacokinetics; Introduction; Drugs and the Older Population; Pharmacokinetics, Pharmacodynamics and Drug Effects 327 $aFactors Influencing Pharmacokinetics in Older PeopleAge Related Changes in Drug Absorption and Bioavailability; Absorption; First Pass Metabolism and Bioavailability; Age Related Changes in Drug Distribution; Volume of Distribution; Protein Binding; Age Related Changes in Drug Clearance; Age Related Changes in Renal Excretion; Age Related Changes in Hepatic Clearance; Phase 1 Metabolism and Ageing; Factors Contributing to Age Related Reductions in Liver Metabolism; Phase 2 Metabolism and Ageing; Frailty, Disease and Drug Metabolism; Frailty; Disease; Conclusions; Research Work to Date 327 $aDirections for Future ResearchReferences; CHAPTER 5 Pharmacodynamics; Introduction; Important Age-associated Pharmacodynamic Changes; Mechanisms of Pharmacodynamic Changes; Cardiovascular Drugs; Vascular Responses; Blood Pressure Lowering Drugs; Central Nervous System Drugs; Conclusions and Suggestions for Future Research; References; CHAPTER 6 Adverse Drug Reactions; Introduction; Definitions; ADRs and Hospital Admission; Studies in Hospital and Nursing Homes; Studies in Ambulatory Settings; Causes; Class of Drugs; Age; Number of Drugs; Consequences and Outcome 327 $aReports to Drug Regulatory Authorities 330 $aThis book is designed for all those with a scientific interest in drug treatment and the older population. The authors have all been chosen for their expertise in the field and have been drawn from both sides of the Atlantic and South Africa. The contents fall into two parts - general principles of drug use as they apply to the elderly, and specific chapters dealing with common clinical areas. The editors aim to provide a concise up to date, evidence-based, resource book. 606 $aGeriatric pharmacology 608 $aElectronic books. 615 0$aGeriatric pharmacology. 676 $a615.5/8/0846 701 $aCrome$b Peter$0894787 701 $aFord$b Gary$g(Gary A.)$0894788 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910449881403321 996 $aDrugs and the older population$91999064 997 $aUNINA