LEADER 05202nam 22006252 450 001 9910449747603321 005 20160208154752.0 010 $a1-107-11669-4 010 $a1-280-15378-4 010 $a9786610153787 010 $a0-511-11747-7 010 $a0-511-04043-1 010 $a0-511-15325-2 010 $a0-511-32781-1 010 $a0-511-54579-7 010 $a0-511-05198-0 035 $a(CKB)1000000000005845 035 $a(EBL)201767 035 $a(OCoLC)559201703 035 $a(SSID)ssj0000216626 035 $a(PQKBManifestationID)11202732 035 $a(PQKBTitleCode)TC0000216626 035 $a(PQKBWorkID)10198398 035 $a(PQKB)10490681 035 $a(UkCbUP)CR9780511545795 035 $a(MiAaPQ)EBC201767 035 $a(Au-PeEL)EBL201767 035 $a(CaPaEBR)ebr10030944 035 $a(CaONFJC)MIL15378 035 $a(EXLCZ)991000000000005845 100 $a20090507d2000|||| uy| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe osteoporosis primer /$fedited by Janet E. Henderson and David Goltzman$b[electronic resource] 210 1$aCambridge :$cCambridge University Press,$d2000. 215 $a1 online resource (xiv, 372 pages) $cdigital, PDF file(s) 300 $aTitle from publisher's bibliographic system (viewed on 05 Oct 2015). 311 $a0-521-64446-1 320 $aIncludes bibliographical references and index. 327 $gPreface /$rJanet E. Henderson and David Goltzman --$gPart I.$tMolecular and Cellular Environment of Bone --$tEndochondral bone formation and development in the axial and appendicular skeleton /$rA. Robin Poole, Sheila Laverty and Fackson Mwale --$tThe role of osteoblasts /$rJane E. Aubin --$tOsteoclasts : characteristics and regulation of formation and activity /$rJohan Heersche and Morris F. Manolson --$tBone matrix proteins /$rMarc D. McKee and Jaro Sodek --$tLocal regulators of bone turnover /$rLawrence J. Fraher and Patricia H. Watson --$tThe PTH/PTHrP system and calcium homeostasis /$rGeoffrey N. Hendy --$tVitamin D metabolism /$rMarielle Gascon-Barre --$tSodium-dependent phosphate transport in kidney, bone and intestine /$rHarriet S. Tenenhouse --$gPart II.$tDeterminants of Peak Bone Mass --$tMolecular genetic analysis of growth factor signalling in bone /$rJanet E. Henderson and David Goltzman --$tGenetic determinants of osteoporosis /$rMilan S. Patel, Laurence A. Rubin and David E.C. Cole --$tNon-genetic determinants of peak bone mass /$rVelimir Matkovic and John D. Landoll --$tBone mineral acquisition during childhood and adolescence : physical exercise as a preventative measure /$rHeather A. McKay and Karim M. Khan --$tOsteoporosis in children /$rFrank Rauch and Francis H. Glorieux --$gPart III.$tPathophysiology of the Aging Skeleton --$tConsequences of alterations in bone remodeling /$rKaren Prestwood and Lawrence G. Raisz --$tThe role of parathyroid hormone and hyperparathyroidism in osteoporosis /$rPierre D'Amour --$tSenile osteoporosis /$rPatrick M. Doran and Sundeep Khosla --$gPart IV.$tClinical Aspects of Osteoporosis --$tEpidemiology /$rJaques Brown --$tBiochemical markers of bone turnover /$rDavid Hanley --$tRadiologic assessment of osteoporosis /$rJaqueline C. Hodge --$tBone mineral density measurements /$rPaul D. Miller and Carol Zapalowski --$tHormone replacement therapy /$rJonathan D. Adachi and Alexandra Papaioannou --$tSelective estrogen receptor modulators /$rFelicia Cosman and Robert Lindsay --$tBisphosphonate therapy of osteoporosis /$rFred Singer and Payam Minoofar --$tThe action of fluoride on bone /$rMarc D. Grynpas, D. Chachra and H. Limeback --$tPTH peptides as anabolic agents in bone /$rAnthony B. Hodsman --$tVitamin D and Vitamin D analogs as therapeutic agents /$rRichard Kremer. 330 $aOsteoporosis is one of the leading causes of morbidity and mortality amongst the elderly. The rationale for The Osteoporosis Primer is to provide an introductory text that relates the clinical presentation of osteoporosis to its molecular biochemical basis. The text has been organised into four sections that deal with the molecular/cellular components of bone, the development of peak bone mass, the pathophysiology of aging bone and, finally, how all of these relate to the prevention, diagnosis and treatment of osteoporosis. The international team of authors includes many leading clinicians and scientists who have provided the reader with a concise, yet comprehensive, synopsis of bone development and skeletal homeostasis. This will be an essential introduction for individuals working on osteoporosis including students and doctors considering a career related to metabolic bone disease, physicians in general practice, geriatricians, rheumatologists, and endocrinologists. 606 $aOsteoporosis 615 0$aOsteoporosis. 676 $a616.7/16 702 $aHenderson$b Janet E.$f1943- 702 $aGoltzman$b David$f1944- 801 0$bUkCbUP 801 1$bUkCbUP 906 $aBOOK 912 $a9910449747603321 996 $aThe osteoporosis primer$92441740 997 $aUNINA