LEADER 05074nam 22006494a 450 001 9910446331103321 005 20200520144314.0 010 $a1-280-73565-1 010 $a9786610735655 010 $a1-84593-084-3 035 $a(CKB)1000000000344500 035 $a(EBL)289443 035 $a(OCoLC)476045175 035 $a(SSID)ssj0000229642 035 $a(PQKBManifestationID)11203517 035 $a(PQKBTitleCode)TC0000229642 035 $a(PQKBWorkID)10172711 035 $a(PQKB)10466340 035 $a(MiAaPQ)EBC289443 035 $a(Au-PeEL)EBL289443 035 $a(CaPaEBR)ebr10157923 035 $a(CaONFJC)MIL73565 035 $a(EXLCZ)991000000000344500 100 $a20050902d2006 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aProtein turnover /$fJ.C. Waterlow 205 $a1st ed. 210 $aWallingford, UK ;$aCambridge, MA $cCABI Pub.$dc2006 215 $a1 online resource (313 p.) 300 $aRev. ed. of: Protein turnover in mammalian tissues and in the whole body. Amsterdam ; New York : Elsevier North-Holland, 1978. 311 $a0-85199-613-2 320 $aIncludes bibliographical references and index. 327 $aContents; Foreword; Acknowledgements; 1 Basic Principles; 1.1 Definitions; 1.2 Notation; 1.3 Equivalence of Tracer and Tracee; 1.4 The Kinetics of Protein Turnover; 1.5 References; 2 Models and Their Analysis; 2.1 Models; 2.2 Compartmental Analysis; 2.3 Stochastic Analysis; 2.4 References; 3 Free Amino Acids: Their Pools, Kinetics and Transport; 3.1 Amino Acid Pools; 3.2 Nutritional Effects on the Free Amino Acid Pools; 3.3 Kinetics of Free Amino Acids; 3.4 Amino Acid Transport Across Cell Membranes; 3.5 Conclusion; 3.6 References; 4 Metabolism of Some Amino Acids; 4.1 Leucine; 4.2 Glycine 327 $a4.3 Alanine4.4 Glutamine; 4.5 Glutamic acid; 4.6 Phenylalanine; 4.7 Arginine; 4.8 Methionine; 4.9 References; 5 The Precursor Problem; 5.1 Transfer-RNA as the Precursor for Synthesis; 5.2 A 'Reciprocal' Metabolite as Precursor; 5.3 A Rapidly Synthesized Protein as Precursor; 5.4 Conclusion; 5.5 References; 6 Precursor Method: Whole Body Protein Turnover Measured by the Precursor Method; 6.1 Background; 6.2 Outline of the Method; 6.3 Variability of Whole Body Synthesis Rates in Healthy Adults by the Precursor Method; 6.4 Sites of Administration and of Sampling; 6.5 Priming 327 $a6.6 The First-pass Effect6.7 Recycling; 6.8 Regional Turnover; 6.9 Measurement of Protein Turnover with Amino Acids other than Leucine; 6.10 Conclusion; 6.11 References; 7 Measurement of Whole Body Protein Turnover by the End-product Method; 7.1 History; 7.2 Theory; 7.3 Alternative End-products (EP); 7.4 Measurement of Flux with a Single End-product; 7.5 Behaviour of Different Amino Acids in the End-product Method: Choice of Glycine; 7.6 Comparisons of Different Protocols; 7.7 Summary of Measurements of Protein Synthesis in Normal Adults by the End-product Method; 7.8 Variability 327 $a7.9 Comparison of Synthesis Rates Measured by the End-product and Precursor Methods7.10 Comparison of Oxidation Rates by the Two Methods; 7.11 The Flux Ratio; 7.12 Kinetics Findings by the End-product Method; 7.13 Conclusion; 7.14 References; 8 Amino Acid Oxidation and Urea Metabolism; 8.1 Amino Acid Oxidation; 8.2 Metabolism of Urea; 8.3 References; 9 The Effects of Food and Hormones on Protein Turnover in the Whole Body and Regions; 9.1 The Immediate Effects of Food; 9.2 The Effects of Hormones on Protein Turnover in the Whole Body, Limb or Splanchnic Region; 9.3 References 327 $a10 Adaptation to Different Protein Intakes: Protein and Amino Acid Requirements10.1 Adaptation; 10.2 Requirements for Protein and Amino Acids; 10.3 References; 11 Physiological Determinants of Protein Turnover; 11.1 Body Size - the Contribution of Allometry; 11.2 Growth and its Cost; 11.3 The Effect of Muscular Activity and Immobility on Protein Turnover; 11.4 Conclusion; 11.5 References; 12 Whole Body Protein Turnover at Different Ages and in Pregnancy and Lactation; 12.1 Premature Infants; 12.2 Neonates; 12.3 Infants 6 months-2 years; 12.4 Older Children; 12.5 Pregnancy; 12.6 Lactation 327 $a12.7 The Elderly 330 $aWritten by the leading authority in the area, this book provides a comprehensive review of the growing body of research on protein turnover in man and animals that has accumulated over the past 20 years. It focuses on protein metabolism at the physiological level, and particularly with studies on human beings. 606 $aProteins$xMetabolism 606 $aMammals$xPhysiology 615 0$aProteins$xMetabolism. 615 0$aMammals$xPhysiology. 676 $a612.3/98 700 $aWaterlow$b J. C$g(John Conrad)$0858995 701 $aWaterlow$b J. C$g(John Conrad).$00 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910446331103321 996 $aProtein turnover$91917183 997 $aUNINA