LEADER 03148oam 2200505 450 001 9910444254303321 005 20220630152146.0 010 $a981-334-033-9 024 7 $a10.1007/978-981-33-4033-6 035 $a(CKB)4100000011759619 035 $a(DE-He213)978-981-33-4033-6 035 $a(MiAaPQ)EBC6476035 035 $a(PPN)253857295 035 $a(EXLCZ)994100000011759619 100 $a20210701d2020 uy 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aQuantitative physiology $esystems approach /$fShangbin Chen, Alexey Zaikin 205 $a1st ed. 2020. 210 1$aSingapore :$cSpringer,$d[2020] 210 4$dŠ2020 215 $a1 online resource (XXI, 237 p. 246 illus., 97 illus. in color.) 311 $a981-334-032-0 327 $aIntroduction of Quantitative Physiology -- Systems and Modelling -- Relevant Resources -- Modelling Gene Expression -- Bone and Body Mechanics -- Blood Dynamics -- Metabolic Network -- Systems pharmacology -- Calcium Signalling -- Modelling Neural Activity -- Cortical Spreading Depression (CSD) -- Heart Physiome -- Constructing genetic intelligence -- Brain Project. 330 $aStephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics. 606 $aPhysiology$xMathematical models 606 $aFisiologia$2thub 606 $aModels matemātics$2thub 608 $aLlibres electrōnics$2thub 615 0$aPhysiology$xMathematical models. 615 7$aFisiologia 615 7$aModels matemātics 676 $a571.015118 700 $aChen$b Shangbin$0929066 702 $aZaikin$b Alexey 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bUtOrBLW 906 $aBOOK 912 $a9910444254303321 996 $aQuantitative physiology$92088034 997 $aUNINA