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010   $a1-283-63018-4
010   $a9786613942630
010   $a3-642-30331-5
024 7 $a10.1007/978-3-642-30331-9
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035   $a(EBL)994563
035   $a(OCoLC)808484299
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035   $a(PQKBTitleCode)TC0000738913
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035   $a(DE-He213)978-3-642-30331-9
035   $a(MiAaPQ)EBC994563
035   $a(PPN)168316447
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100   $a20120814d2013      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aProspects for Chemoprevention of Colorectal Neoplasia$b[electronic resource] $eEmerging Role of Anti-Inflammatory Drugs /$fedited by Andrew T. Chan, Elmar Detering
205   $a1st ed. 2013.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013.
215   $a1 online resource (185 p.)
225 1 $aRecent Results in Cancer Research,$x0080-0015 ;$v191
300   $aDescription based upon print version of record.
311   $a3-642-43447-9 
311   $a3-642-30330-7 
320   $aIncludes bibliographical references.
327   $aWhat is chemoprevention today?- Mechanistic aspects in tumor development and progression of colorectal adenoma and carcinoma -- Mode of action of  aspirin as a chemopreventive agent -- Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials -- COX-2 active agents in chemoprevention (includes aspirin, coxibs, and DFMO) -- New potential developments in aspirin/NSAID derivatives -- Aspirin in CRC chemoprevention in the context of other chronic diseases -- Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal adenoma and carcinoma -- Genetic risks for CRC and hereditary forms of CRC. ? Strategies for prevention in high risk population.
330   $aThe prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammatory properties is considered, and strategies applicable in those with a high level of genetic risk are evaluated. An important feature of the book is its holistic perspective, making it relevant for gastroenterologists, internists, general practitioners, oncologists, colorectal and gastroenterological surgeons, and public health practitioners.
410  0$aRecent Results in Cancer Research,$x0080-0015 ;$v191
606   $aOncology  
606   $aGastroenterology 
606   $aInternal medicine
606   $aCardiology
606   $aRectum?Surgery 
606   $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160
606   $aGastroenterology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33061
606   $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002
606   $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037
606   $aColorectal Surgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H59036
615  0$aOncology  .
615  0$aGastroenterology .
615  0$aInternal medicine.
615  0$aCardiology.
615  0$aRectum?Surgery .
615 14$aOncology.
615 24$aGastroenterology.
615 24$aInternal Medicine.
615 24$aCardiology.
615 24$aColorectal Surgery.
676   $a616.994347
702   $aChan$b Andrew T$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aDetering$b Elmar$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910438134403321
996   $aProspects for Chemoprevention of Colorectal Neoplasia$92230317
997   $aUNINA