LEADER 03419nam 2200589 a 450 001 9910438131503321 005 20200520144314.0 010 $a1-283-61246-1 010 $a9786613924919 010 $a0-85729-209-9 024 7 $a10.1007/978-0-85729-209-4 035 $a(CKB)2670000000241321 035 $a(EBL)972296 035 $a(OCoLC)808814488 035 $a(SSID)ssj0000739414 035 $a(PQKBManifestationID)11458064 035 $a(PQKBTitleCode)TC0000739414 035 $a(PQKBWorkID)10688679 035 $a(PQKB)10048119 035 $a(DE-He213)978-0-85729-209-4 035 $a(MiAaPQ)EBC972296 035 $a(PPN)16828880X 035 $a(EXLCZ)992670000000241321 100 $a20120907d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aStroke genetics /$fPankaj Sharma, James F. Meschia, editors 205 $a1st ed. 2013. 210 $aLondon $cSpringer$d2013 215 $a1 online resource (332 p.) 300 $aDescription based upon print version of record. 311 $a1-4471-6176-9 311 $a0-85729-208-0 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Candidate Gene Association Studies in Stroke -- Genome-Wide Association Studies (GWAS) -- The Genetics of Cerebral Aneurysms and Other Vascular Malformations -- Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy -- Clinicogenetic and Pathologic Characteristics of CADASIL -- Monogenic Disorder: Fabry Disease -- Stroke-like Episodes in Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) -- Genetics of Sickle Cell Disease and Stroke -- Other Monogenetic Stroke Disorders -- White Matter Disease -- Genetics of Carotid Disease -- Genetics of Cervical Artery Dissection -- Stroke Pharmacogenetics -- Ethical Issues in the Genetics of Complex Disorders. 330 $aOver the last decade there has been a substantial increase in our understanding of the genetic basis of common disorders such as stroke. Stroke Genetics is designed to give the reader an overall understanding of the genetics of complex diseases by using stroke as a paradigm. The reader will gain a comprehensive understanding of cerebrovascular genetics including the epidemiological evidence for the genetic basis of ischemic and hemorrhagic stroke, knowledge of its molecular basis from association, linkage and recent genome-wide studies, and also monogenic disorders. Finally, the legal and ethical complexities in dealing with these issues are discussed.   Stroke Genetics benefits from the contribution of renowned experts from throughout the world who have been intimately involved in unraveling the genetic etiology of stroke. Stroke Genetics is a valuable resource for neurologists, stroke physicians, hypertension specialists, internists, clinical pharmacologists and those in training, as well as researchers in the field of disease genetics. 606 $aCerebrovascular disease$xGenetic aspects 615 0$aCerebrovascular disease$xGenetic aspects. 676 $a616.81042 676 $a616.81042 701 $aSharma$b Pankaj$0769368 701 $aMeschia$b James F$01643698 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438131503321 996 $aStroke Genetics$94156210 997 $aUNINA