LEADER 03256nam 2200577Ia 450 001 9910438129503321 005 20200520144314.0 010 $a1-4614-6561-3 024 7 $a10.1007/978-1-4614-6561-4 035 $a(CKB)2550000001043728 035 $a(EBL)1205334 035 $a(SSID)ssj0000878511 035 $a(PQKBManifestationID)11482771 035 $a(PQKBTitleCode)TC0000878511 035 $a(PQKBWorkID)10836549 035 $a(PQKB)11722339 035 $a(DE-He213)978-1-4614-6561-4 035 $a(MiAaPQ)EBC1205334 035 $a(PPN)16913640X 035 $a(EXLCZ)992550000001043728 100 $a20130410d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAutophagy and cancer /$fHong-Gang Wang, editor 205 $a1st ed. 2013. 210 $aNew York, NY $cSpringer$dc2013 215 $a1 online resource (261 p.) 225 1 $aCurrent cancer research ;$v8 300 $aIncludes index. 311 $a1-4899-9177-8 311 $a1-4614-6560-5 327 $aPreface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index. 330 $aThis book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer. 410 0$aCurrent cancer research ;$v8. 606 $aCarcinogenesis 606 $aCancer$xImmunological aspects 615 0$aCarcinogenesis. 615 0$aCancer$xImmunological aspects. 676 $a571.9 676 $a571.9/36 701 $aWang$b Hong-Gang$01755298 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438129503321 996 $aAutophagy and cancer$94192030 997 $aUNINA