LEADER 06839nam 22008535 450 001 9910438129103321 005 20211202202613.0 010 $a1-283-61262-3 010 $a9786613925077 010 $a3-642-27994-5 024 7 $a10.1007/978-3-642-27994-2 035 $a(CKB)2670000000250221 035 $a(EBL)972233 035 $a(OCoLC)809202728 035 $a(SSID)ssj0000739544 035 $a(PQKBManifestationID)11434409 035 $a(PQKBTitleCode)TC0000739544 035 $a(PQKBWorkID)10688316 035 $a(PQKB)10248082 035 $a(DE-He213)978-3-642-27994-2 035 $a(MiAaPQ)EBC972233 035 $a(PPN)168311283 035 $a(EXLCZ)992670000000250221 100 $a20120823d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTheranostics, Gallium-68, and Other Radionuclides$b[electronic resource] $eA Pathway to Personalized Diagnosis and Treatment /$fedited by Richard P. Baum, Frank Rösch 205 $a1st ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (567 p.) 225 1 $aRecent Results in Cancer Research,$x0080-0015 ;$v194 300 $aDescription based upon print version of record. 311 $a3-642-44160-2 311 $a3-642-27993-7 320 $aIncludes bibliographical references. 327 $aTheranostics, Gallium-68,and Other Radionuclides; Contents; Part IGenerators; 1 68Ge/68Ga Generators: Past, Present, and Future; Abstract; 1...Introduction; 2...The Early Years (1960--1970): The Dawn of 68Ga; 2.1 Further Generator Developments: Al2O3-Based EDTA-Eluted Generators; 2.2 68Ga-EDTA: The PET Pharmaceutical, Development of Positron Scintillation Cameras; 3...Hibernating 68Ga Medical Applications, but New Chemistry Ahead; 4...Commercial ''Ionic'' Generators; 5...Current State/Outlook; References; 2 Overview and Perspectives on Automation Strategies in 68Ga Radiopharmaceutical Preparations 327 $aAbstract1...Introduction; 2...Approach to Automation: Considerations on 68Ga Radiolabeling Process; 3...Modules for 68Ga Radiopharmaceuticals; 3.1 Classification and Characteristics of Automated Systems; 3.2 Automation and Regulatory Aspects; 4...Perspectives; References; 3 Post-Processing via Cation Exchange Cartridges: Versatile Options; Abstract; 1...Introduction; 2...The Initial Cation Exchange-Based Post-Purification Concept; 3...Combined Cation and Anion Exchange-Based Post-Processing; 4...Post-Processing Towards Nonaqueous Systems for Labeling Lipophilic Compounds 327 $a5...Instant Quantification of Generator 68Ge Breakthrough6...Conclusions; References; 4 68Ga Generator Integrated System: Elution--Purification--Concentration Integration; Abstract; 1...Introduction; 2...Nuclear Characteristics and Radioactive Transformation Equilibrium; 3...68Ge/68Ga Separation and 68Ga Generator; 3.1 Nanocrystalline Ceramic Structure Sorbent Used for Chromatographic 68Ge/68Ga Separation; 3.2 68Ga Generator Setup; 3.3 Generator Operation and Specification; 3.4 68Zn2+ Formation and Its Influence on Coordination Chemistry of 68Ga-Radiolabeling 327 $a4...Post-Elution Purification--Concentration of 68Ga Eluate4.1 Salt-Form Cationic Exchange Resin-Based Purification--Concentration Method; 4.2 Automation Process and Setup of 68Ga Radioisotope Generator Integrated System (RADIGIS-68Ga); 4.3 Basic/Acidic 68Ga Eluates and Their Radiolabeling; 4.4 Performance of 68Ga Generator and 68Ga Radioisotope Generator Integrated System; 5...Quality Evaluation Experiments: Quality Control Protocols and Radiolabeling Efficacy Evaluation; 5.1 Quality Evaluation of 68Ga Solution; 5.1.1 Quality Control Procedures 327 $a5.1.2 Radiolabeling Efficacy Evaluation Based on Radiolabeling Ligands DOTATOC and DOTATATE with 68Ga Solution5.2 Operation Performance Assessment of Ga-68 Generator Systems; Acknowledgments; References; 5 Purification and Labeling Strategies for 68Ga from 68Ge/68Ga Generator Eluate; Abstract; 1...Introduction; 1.1 History; 1.2 Current State; 1.3 Basic Methods; 1.3.1 Anionic Purification; 1.3.2 Cationic Purification; 1.3.3 Fractional Elution; 2...Combined Cationic--Anionic Purification of 68Ge/68Ga Generator Eluate for Labeling of Fragile Peptides and Proteins; 2.1 Aim; 2.2 Description 327 $a2.3 Advantages 330 $aThis book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics ? the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases.  In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy. 410 0$aRecent Results in Cancer Research,$x0080-0015 ;$v194 606 $aOncology   606 $aNuclear medicine 606 $aNeuroradiology 606 $aRadiotherapy 606 $aMolecular biology 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 606 $aNuclear Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H29048 606 $aNeuroradiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H2903X 606 $aRadiotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H29056 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 615 0$aOncology  . 615 0$aNuclear medicine. 615 0$aNeuroradiology. 615 0$aRadiotherapy. 615 0$aMolecular biology. 615 14$aOncology. 615 24$aNuclear Medicine. 615 24$aNeuroradiology. 615 24$aRadiotherapy. 615 24$aMolecular Medicine. 676 $a610.28/4 676 $a610.284 702 $aBaum$b Richard P.$f1954-$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aRösch$b Frank$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910438129103321 996 $aTheranostics, Gallium-68, and Other Radionuclides$92129702 997 $aUNINA