LEADER 04673nam 22007815 450 001 9910438116003321 005 20251230064624.0 010 $a94-007-4923-6 024 7 $a10.1007/978-94-007-4923-8 035 $a(CKB)3400000000115804 035 $a(SSID)ssj0000877641 035 $a(PQKBManifestationID)11465860 035 $a(PQKBTitleCode)TC0000877641 035 $a(PQKBWorkID)10812066 035 $a(PQKB)11642725 035 $a(DE-He213)978-94-007-4923-8 035 $a(MiAaPQ)EBC3070858 035 $a(PPN)168339412 035 $a(EXLCZ)993400000000115804 100 $a20121204d2013 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt 182 $cc 183 $acr 200 10$aBiophysics and Structure to Counter Threats and Challenges /$fedited by Joseph D. Puglisi, Manolia V. Margaris 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (X, 169 p. 68 illus.) 225 1 $aNATO Science for Peace and Security Series B: Physics and Biophysics,$x1874-6535 300 $a"Proceedings of the NATO Advanced Study Institute on Biophysics and Structure to Counter Threats and Challenges, Erice, Sicily, Italy, 22 June - 2 July, 2010". 300 $aInternational conference proceedings. 311 08$a94-007-4922-8 320 $aIncludes bibliographical references and index. 327 $aFrom the Contents: Macromolecular Models by Single Molecule FRET -- System-specific  scoring Functions; Application to Guanine-containing Ligands and Thrombin -- Large DNA Template Dependent Error Variation during Transcription -- Structures of Novel HIV-inactivating Lectins -- Fluorescence Resonance Energy Transfer Studies of Structure and Dynamics in Nucleic Acids -- An Introduction to Macromolecular Crystallography through Parable and Analogy -- Using NMR to determine the Conformation of the HIV reverse Transcription Initiation Complex -- Approaches to Protein-ligand Structure Determination by NMR Spectroscopy: Applications in Drug Binding to the Cardiac Regulatory Protein Troponin C -- How do Nascent Proteins emerge from the Ribosome? -- Course Abstracts and Posters -- Author Index. 330 $aThis ASI brought together a diverse group of experts who span virology, biology, biophysics, chemistry, physics and engineering.  Prominent lecturers representing world renowned scientists from nine (9) different countries, and students from around the world representing eighteen (18) countries, participated in the ASI organized by Professors Joseph Puglisi (Stanford University, USA) and Alexander Arseniev (Moscow, RU).   The central hypothesis underlying this ASI was that interdisciplinary research, merging principles of physics, chemistry and biology, can drive new discovery in detecting and fighting chemical and bioterrorism agents, lead to cleaner environments and improved energy sources, and help propel development in NATO partner countries.  At the end of the ASI students had an appreciation of how to apply each technique to their own particular research problem and to demonstrate that multifaceted approaches and new technologies are needed to solve the biological challenges of our time.  The course succeeded in training a new generation of biologists and chemists who will probe the molecular basis for life and disease. 410 0$aNATO Science for Peace and Security Series B: Physics and Biophysics,$x1874-6535 606 $aBiophysics 606 $aCondensed matter 606 $aCrystallography 606 $aBiotechnology 606 $aChemistry, Physical and theoretical 606 $aBiophysics 606 $aCondensed Matter Physics 606 $aCrystallography and Scattering Methods 606 $aBiotechnology 606 $aTheoretical Chemistry 615 0$aBiophysics. 615 0$aCondensed matter. 615 0$aCrystallography. 615 0$aBiotechnology. 615 0$aChemistry, Physical and theoretical. 615 14$aBiophysics. 615 24$aCondensed Matter Physics. 615 24$aCrystallography and Scattering Methods. 615 24$aBiotechnology. 615 24$aTheoretical Chemistry. 676 $a571.4 701 $aPuglisi$b Joseph D$01750246 701 $aMargaris$b Manolia V$01750247 712 12$aNATO Advanced Study Institute on Biophysics and Structure to Counter Threats and Challenges 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438116003321 996 $aBiophysics and structure to counter threats and challenges$94184837 997 $aUNINA