LEADER 04468nam 2200661 a 450 001 9910438113703321 005 20200520144314.0 010 $a1-283-64030-9 010 $a1-4614-4370-9 024 7 $a10.1007/978-1-4614-4370-4 035 $a(CKB)3400000000086016 035 $a(EBL)994685 035 $a(OCoLC)812173775 035 $a(SSID)ssj0000767065 035 $a(PQKBManifestationID)11478196 035 $a(PQKBTitleCode)TC0000767065 035 $a(PQKBWorkID)10733095 035 $a(PQKB)10272943 035 $a(DE-He213)978-1-4614-4370-4 035 $a(MiAaPQ)EBC994685 035 $a(PPN)16830001X 035 $a(EXLCZ)993400000000086016 100 $a20120611d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aIntracellular signaling mediators in the circulatory and ventilatory systems /$fMarc Thiriet 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (1070 p.) 225 0$aBiomathematical and biomechanical modeling of the circulatory and ventilatory systems,$x2193-1682 ;$vv. 4 300 $aDescription based upon print version of record. 311 $a1-4614-4369-5 320 $aIncludes bibliographical references and index. 327 $a1. Introduction -- 2. Signaling Lipids -- 3. Preamble to Cytoplasmic Protein Kinases -- 4. Cytoplasmic Protein Tyrosine Kinases -- 5. Cytoplasmic Protein Serine/Threonine Kinases -- 6. Dual-Specificity Protein Kinases -- 7. Mitogen-Activated Protein Kinase Module -- 8. Dual-Specificity Protein Kinases -- 9. Guanosine Triphosphatases and Their Regulators -- 10. Other Major Types of Signaling Mediators -- 11. Signaling Pathways -- 12. Conclusion -- References -- List of Currently Used Prefixes and Suffixes -- List of Aliases.-Complementary Lists of Notations -- Index. 330 $aThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors.  Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled.  Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function Describes ion and molecular carriers and receptors Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows. 410 0$aBiomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems,$x2193-1682 ;$v4 606 $aCellular signal transduction 606 $aCellular control mechanisms 606 $aCardiovascular system 606 $aCardiopulmonary system 606 $aRespiratory organs 615 0$aCellular signal transduction. 615 0$aCellular control mechanisms. 615 0$aCardiovascular system. 615 0$aCardiopulmonary system. 615 0$aRespiratory organs. 676 $a571.74 700 $aThiriet$b Marc$0791327 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438113703321 996 $aIntracellular Signaling Mediators in the Circulatory and Ventilatory Systems$92266072 997 $aUNINA