LEADER 05894nam 2200649 a 450 001 9910438025603321 005 20200520144314.0 010 $a1-283-91181-7 010 $a88-470-2670-9 024 7 $a10.1007/978-88-470-2670-4 035 $a(CKB)2670000000309385 035 $a(EBL)1083478 035 $a(OCoLC)823386708 035 $a(SSID)ssj0000811729 035 $a(PQKBManifestationID)11429903 035 $a(PQKBTitleCode)TC0000811729 035 $a(PQKBWorkID)10851402 035 $a(PQKB)10058652 035 $a(DE-He213)978-88-470-2670-4 035 $a(MiAaPQ)EBC1083478 035 $a(PPN)16833450X 035 $a(EXLCZ)992670000000309385 100 $a20120711d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRectal cancer $estrategy and surgical techniques /$fNicolo de Manzini, editor ; forewords by Gianluigi Melotti, Christian Meyer 205 $a1st ed. 2013. 210 $aMilan ;$aNew York $cSpringer$dc2013 215 $a1 online resource (213 p.) 225 0$aUpdates in surgery,$x2280-9848 300 $aDescription based upon print version of record. 311 $a88-470-2669-5 320 $aIncludes bibliographical references and index. 327 $aTitle Page; Copyright Page; Foreword; Foreword; Preface; Table of Contents; Contributors; 1 Epidemiology; 1.1 Introduction; 1.2 World; 1.2.1 USA; 1.2.2 Italy; 1.2.3 Conclusions; 1.3 Risk Factors; 1.3.1 Conclusions; References; 2 Pretherapeutic Diagnosis and Staging; 2.1 Introduction; 2.2 The Role of the Different Imaging Techniques in the Staging of Rectal Cancer; 2.2.1 Endoluminal Ultrasound; 2.2.2 Computed Tomography; 2.2.3 Magnetic Resonance Imaging; 2.3 MR Imaging - Technical Aspects; 2.4 Anatomy of the Rectum for Interpretation of MR Images 327 $a2.5 MRI in the Primary Staging of Rectal Cancer2.5.1 T-staging; 2.5.2 Locally Advanced Rectal Cancer; 2.5.3 N staging; 2.5.4 Circumferential Resection Margin; 2.6 MRI after Neoadjuvant Chemoradiation Therapy; References; 3 Pathology; 3.1 Introduction; 3.2 Role of the Surgeon; 3.3 Role of the Pathologist (Grossing Phase); 3.4 Role of the Pathologist (Microscopic Phase); References; 4 Molecular Parameters for Prognostic and Predictive Assessment in Colorectal Cancer; 4.1 Introduction; 4.2 Molecular Genetics of Colorectal Cancer; 4.3 Molecular Markers for Early Cancer Detection 327 $a4.4 Molecular Markers for Prognostic Assessment4.4.1 Prognostic Value of Genetic and Epigenetic Tumor Characteristics; 4.4.2 Prognostic Value of Individual Genetic Mutations; 4.4.3 Prognostic Value of Gene Expression Profiling; 4.4.4 Prognostic Value of Immune Cell Infiltration; 4.5 Molecular Markers Predicting Response to Therapy; 4.5.1 Predictive Value of Genetic and Epigenetic Tumor Characteristics; 4.5.2 Predictive Value of Specific Genetic Variations; 4.5.3 Predictive Value of Gene Expression Profiling; 4.5.4 Genetic Polymorphisms Affecting Drug Efficacy 327 $a4.5.5 The Tumor Microenvironment and its Predictive Potential4.6 Peculiarity of Rectal Cancer; References; 5 Neo- and Adjuvant Therapy; 5.1 Introduction; 5.2 Integrating New Drugs in Combined Modality of Neoadjuvant and Adjuvant Treatment of Rectal Cancer; 5.2.1 Chemotherapy; 5.2.2 Biological Agents; 5.3 Palliative Therapy (Stage IV at Diagnosis); References; 6 Perioperative Treatment; 6.1 Introduction; 6.2 Intestinal Preparation; 6.3 Anesthesia; 6.3.1 Pre-anesthetic Medication; 6.3.2 Managing Infusion Therapy in the Perioperative Period; 6.3.3 Postoperative Analgesia 327 $a6.4 Antithrombotic Prophylaxis6.5 Antibiotic Prophylaxis; 6.6 Nutrition; 6.6.1 Preoperative Nutrition; 6.6.2 Postoperative Nutrition; 6.7 Nasogastric Probe (NGP); 6.8 Bladder Catheter; 6.9 Abdominal Drainage; 6.10 Quick Mobilization; 6.11 Conclusions; References; 7 Surgical Technique; 7.1 Introduction; 7.2 Position of the Patient and the Surgical Team; 7.3 Surgical Anatomy; 7.4 An Important Issue: Margins; 7.5 Vascular Phase; 7.6 Pelvic Phase; 7.7 PME and TME; 7.8 Intersphincteric Resection; 7.9 Abdomino-perineal Amputation; 7.10 TEM; 7.11 Hartmann; References 327 $a8 Nerve-sparing Technique in Rectal Cancer 330 $aThis book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages. 410 0$aUpdates in Surgery,$x2280-9848 606 $aRectum$xCancer 615 0$aRectum$xCancer. 676 $a616.99435059 701 $aManzini$b Nicolo de$01755755 701 $aMelotti$b Gianluigi$01755756 701 $aMeyer$b Christian$0345059 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438025603321 996 $aRectal cancer$94192656 997 $aUNINA