LEADER 06272nam 22006615 450 001 9910438020503321 005 20200706012826.0 010 $a1-4471-4881-9 024 7 $a10.1007/978-1-4471-4881-4 035 $a(CKB)3280000000020510 035 $a(EBL)1205264 035 $a(SSID)ssj0000906857 035 $a(PQKBManifestationID)11474525 035 $a(PQKBTitleCode)TC0000906857 035 $a(PQKBWorkID)10855744 035 $a(PQKB)10797682 035 $a(DE-He213)978-1-4471-4881-4 035 $a(MiAaPQ)EBC1205264 035 $a(PPN)169135233 035 $a(EXLCZ)993280000000020510 100 $a20130423d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aElectrical Diseases of the Heart$b[electronic resource] $eVolume 1: Basic Foundations and Primary Electrical Diseases /$fedited by Ihor Gussak, Charles Antzelevitch 205 $a2nd ed. 2013. 210 1$aLondon :$cSpringer London :$cImprint: Springer,$d2013. 215 $a1 online resource (659 p.) 300 $aDescription based upon print version of record. 311 $a1-4471-4880-0 320 $aIncludes bibliographical references and index. 327 $aBasic Cardiac Electrophysiology- Promises Kept and Promises to Keep -- Basic Physiology of Ion Channel Function -- Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form -- Anatomic and Histopathologic Characteristics of the Conductive Tissues of the Heart -- Neural Regulation of the Heart in Health and Disease -- Mechanisms of Cardiac Arrhythmia -- Mechanisms of Action of Antiarrhythmic Drugs in Ventricular Arrhythmias -- Mechanisms of Action of Antiarrhythmic Drugs in Atrial Fibrillation -- Mechano-Electrical Interactions and their Role in Electrical Function of the Heart -- Pathological Roles of the Cardiac Sodium Channel Late Current (late INa) -- Sodium Ion Channelopathies -- L-Type Calcium Channel Disease -- Nerve Sprouting, Defibrillation and Calcium Waves -- K+ Channelopathies (IKs, IKr, and Ito) -- Cardiac ATP-Sensitive Potassium Channels and Associated Channelopathies -- Cardiac KATP Channels in Health and Diseases -- Ca2+ Release Channels (Ryanodine Receptors) and Arrhythmogenesis -- Caveolae and Arrhythmogenesis -- Senescence and Arrhythmogenesis -- Comparisons of Substrates Responsible for Atrial versus Ventricular Fibrillation -- Single Nucleotide Polymorphisms in Health and Cardiac Disease -- Electrophysiological Remodeling in Heart Failure -- Ventricular Electrical Remodeling in Compensated Cardiac Hypertrophy -- Physiological and Other Biological Pacemakers -- Cardiac Memory: From Electrical Curiosity to Clinical Diagnostic and Research Tool -- Heritable Arrhythmogenic Channelopathies, Primary Electrical Diseases, and Sudden Cardiac Death -- Celebrating the Challenge of Cardiac Arrhythmias -- Congenital Long QT Syndrome -- Brugada Syndrome ? Clinical and Genetic Aspects -- Brugada Syndrome: Cellular Mechanisms and Approaches to Therapy -- Early Repolarization Syndrome: Epidemiology, Genetics, and Risk Stratification -- Catecholaminergic Polymorphic Ventricular Tachycardia -- Andersen-Tawil and Timothy Syndromes -- Short QT Syndrome -- Progressive Cardiac Conduction Disease -- Genetics of Atrial Fibrillation -- Idiopathic Ventricular Fibrillation.              . 330 $aThe past two decades have witnessed an explosion of knowledge and radical changes in our understanding of the molecular, ionic, genetic, and pharmacologic basis of electrical diseases of the heart. Electrical diseases of the heart are heritable arrhythmogenic clinical entities that may share common clinical and genetic features, yet may be distinctly different in their genesis, prognosis, and management. Notably, both congenital and acquired electrical diseases of the heart are receiving increased recognition as a result of important advances in genetic analysis.   In this second edition of Electrical Diseases of the Heart, the Editors? goal has been to embrace and highlight the explosion of knowledge that our field has witnessed since the publication of the first edition.  The approach continues to be one of bridging basic and clinical science in an attempt to advance meaningfully our understanding of heart disease and identify the knowledge gaps that exist. This volume covers the basic foundations and primary electrical diseases and with the companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities.   Residents, fellows and physicians in cardiology and electrophysiology will gain valuable insight into the latest developments in the field of cardiac electrophysiology and clinical electrocardiology by reading this book, including expert review of the genetic and epidemiologic considerations, diagnostic and therapeutic modalities of the newly discovered clinical syndromes and electrocardiographic phenomena, and their correlation with the most recent advances in the basic science. 606 $aCardiology 606 $aEpidemiology 606 $aNeurology  606 $aInternal medicine 606 $aCardiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33037 606 $aEpidemiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H63000 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aInternal Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H33002 615 0$aCardiology. 615 0$aEpidemiology. 615 0$aNeurology . 615 0$aInternal medicine. 615 14$aCardiology. 615 24$aEpidemiology. 615 24$aNeurology. 615 24$aInternal Medicine. 676 $a616.128 702 $aGussak$b Ihor$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aAntzelevitch$b Charles$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910438020503321 996 $aElectrical Diseases of the Heart$92079599 997 $aUNINA