LEADER 03728nam 2200577Ia 450 001 9910438014703321 005 20200520144314.0 010 $a1-299-33629-9 010 $a3-7091-1175-7 024 7 $a10.1007/978-3-7091-1175-8 035 $a(CKB)2670000000328041 035 $a(EBL)1106449 035 $a(OCoLC)827212039 035 $a(SSID)ssj0000878583 035 $a(PQKBManifestationID)11514891 035 $a(PQKBTitleCode)TC0000878583 035 $a(PQKBWorkID)10836051 035 $a(PQKB)10355962 035 $a(DE-He213)978-3-7091-1175-8 035 $a(MiAaPQ)EBC1106449 035 $a(PPN)168331322 035 $a(EXLCZ)992670000000328041 100 $a20130208d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCell-based therapies in stroke /$fJukka Jolkkonen, Piotr Walczak, editors 205 $a1st ed. 2013. 210 $aVienna ;$aNew York $cSpringer$dc2013 215 $a1 online resource (203 p.) 300 $aIncludes index. 311 $a3-7091-1696-1 311 $a3-7091-1174-9 327 $aPreclinical Optimization of Cell Therapies: Cell Therapy and Structural Plasticity Following Cerebral Ischemia.- Delivery Routes for Cell Therapy in Stroke -- Different Sources of Stem Cells for Transplantation Therapy in Stroke -- Efficacy of Transplant and Endogenous Precursor and Stem Cell Interventions on Stroke Recovery -- Translational Imaging Techniques to Study Cell Therapy: Cell Labeling Methods for Non-Invasive MR Imaging of Stem Cells -- Strategies for Enhanced, MRI-guided Targeting of Stem Cells to Stroke Lesions -- Image-guided Injection and Non-invasive Monitoring of Tissue Regeneration in the Stroke-damaged Brain -- Tracking of Autologous VSOP-Labelled Mesenchymal Stem Cells in the Sheep Brain Using 3T MRI -- Neural Stem Cell Mapping With High Resolution Rapid Scanning X-ray Fluorescence Imaging -- In Vivo Biodistribution Studies and Cell Tracking in Stroke Using SPECT Imaging -- Early Phase Clinical Studies: Clinical Trials -- Intravenous Cell Therapies for Stroke -- Intra-arterial Cell Therapy in Stroke Patients -- Intraventricular Route of Cell Transplantation for Stroke-Related Diseases. 330 $aStroke remains one of the main causes of death and disability worldwide. Effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.      . 606 $aCerebrovascular disease$xTreatment 606 $aStem cells$xTherapeutic use 615 0$aCerebrovascular disease$xTreatment. 615 0$aStem cells$xTherapeutic use. 676 $a616.8106 701 $aJolkkonen$b Jukka$01751838 701 $aWalczak$b Piotr$01751839 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438014703321 996 $aCell-based therapies in stroke$94186962 997 $aUNINA