LEADER 03988nam 2200613 a 450 001 9910438005703321 005 20200520144314.0 010 $a1-283-93565-1 010 $a3-7091-1325-3 024 7 $a10.1007/978-3-7091-1325-7 035 $a(CKB)2670000000317448 035 $a(EBL)1083121 035 $a(OCoLC)823727451 035 $a(SSID)ssj0000830673 035 $a(PQKBManifestationID)11437129 035 $a(PQKBTitleCode)TC0000830673 035 $a(PQKBWorkID)10819766 035 $a(PQKB)11215481 035 $a(DE-He213)978-3-7091-1325-7 035 $a(MiAaPQ)EBC1083121 035 $a(PPN)168331462 035 $a(EXLCZ)992670000000317448 100 $a20130108d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aPharmacological potential of selected natural compounds in the control of parasitic diseases /$fGabriela Hrckova, Samuel Velebny 205 $a1st ed. 2013. 210 $aWien ;$aNew York $cSpringer$dc2013 215 $a1 online resource (134 p.) 225 0$aSpringerBriefs in pharmaceutical science & drug development,$x1864-8118 300 $aDescription based upon print version of record. 311 $a3-7091-1324-5 320 $aIncludes bibliographical references. 327 $aProtozoan infections, pathology and therapy -- Current antiprotozoan drugs and problem of resistance -- Natural compounds with direct antiprotozoal activity -- Natural compounds isolated from higher plants -- Bioactive compounds from lower terrestrial organisms -- Marine organisms ? undiscovered source of the potential drugs -- Concluding remarks -- Parasitic helminthes of human and animals: health impact and control -- Anthelmintic drugs ? efficacy, side effects and resistance -- Natural compounds with direct anthelmintic activity -- Anthelmintic potential of higher plants -- Lower terrestrial and marine organisms in anthelmintic drug discovery -- Concluding remarks -- Combined therapy of parasitic infections using substances from natural sources -- Host pathology and immunosuppression during parasitic infections -- Natural compounds with immunomodulatory effects -- Natural compounds with antioxidant and other host-protecting activities -- Summary: perspectives and possibilities in drug discovery from natural sources. 330 $aThe natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. Additionally, the advantages of combined therapy using antiparasitic drugs and natural compounds with selected specific activity are reviewed and explained in the context of host pathology and immunosuppression induced by the parasites. The conclusions of this new book give suggestions for further non-empirical drug development and discuss perspectives of alternative approaches to therapy of parasitic diseases. 410 0$aSpringerBriefs in Pharmaceutical Science & Drug Development,$x1864-8118 606 $aParasitic diseases 606 $aPharmacology 615 0$aParasitic diseases. 615 0$aPharmacology. 676 $a616.96061 676 $a636.0896 700 $aHrckova$b Gabriela$0923895 701 $aVelebny$b Samuel$01751899 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438005703321 996 $aPharmacological potential of selected natural compounds in the control of parasitic diseases$94187042 997 $aUNINA