LEADER 05743nam 2200589Ia 450 001 9910438004303321 005 20200520144314.0 010 $a1-62703-490-0 024 7 $a10.1007/978-1-62703-490-6 035 $a(OCoLC)852391776 035 $a(MiFhGG)GVRL6XLI 035 $a(CKB)2670000000388206 035 $a(MiAaPQ)EBC1317653 035 $a(EXLCZ)992670000000388206 100 $a20111102d2013 uy 0 101 0 $aeng 135 $aurun|---uuuua 181 $ctxt 182 $cc 183 $acr 200 00$aPediatric hypertension /$fJoseph T. Flynn, Julie R. Ingelfinger, Ronald J. Portman, editors 205 $a3rd ed. 2013. 210 $aNew York $cSpringer Science$d2013 215 $a1 online resource (xvi, 600 pages) $cillustrations (some color) 225 0 $aClinical hypertension and vascular diseases 300 $aDescription based upon print version of record. 311 $a1-62703-489-7 320 $aIncludes bibliographical references and index. 327 $aForeword; Preface; Contents; Contributors; Part I: Regulation of Blood Pressure and Pathophysiological Mechanisms of Hypertension; 1: Neurohumoral and Autonomic Regulation of Blood Pressure; Introduction; Overview of Autonomic Function; Vasoactive Sites in the Brain; Tonic Autonomic Activity; Arterial Baroreflex; Resetting of the Arterial Baroreflex; Autonomic Function During Human Development; Cardiopulmonary Reflex; Peripheral Chemoreflex; Sympathetic Activity at Birth; Humoral Factors (See Also Chaps. 1 and 2); Renin-Angiotensin-Aldosterone System; Arginine Vasopressin; Glucocorticoids 327 $aNitric OxideReactive Oxygen Species; Conclusion; References; 2: Vasoactive Factors and Blood Pressure in Children; Introduction; Renin-Angiotensin-Aldosterone System; Angiotensinogen; Prorenin, Renin, and (Pro)renin Receptor; Angiotensin-Converting Enzyme; Angiotensin II Receptors; Angiotensin-Converting Enzyme 2; Developmental Aspects of the RAAS; Aldosterone; Glucocorticoids; Kallikrein-Kinin System; Arginine Vasopressin; Endothelium-Derived Vasoactive Factors; Nitric Oxide; Asymmetrical Dimethylarginine; Endothelin; Natriuretic Peptides 327 $aVasoactive Factors and Developmental Programming of HypertensionRenalase; Summary; References; 3: Cardiovascular Influences on Blood Pressure; Introduction; Cardiac Output; Preload; Venous Tone; Circulating Blood Volume; Cardiopulmonary Baroreceptors; Natriuretic Peptides; The Kidney and Blood Volume; Chronic Changes in Preload and Hypertension; Cardiac Contractility; Chronic Changes in Cardiac Contractility and Hypertension; Afterload; Chronic Increase in Afterload and Myocardial Hypertrophy; Determinants of Systolic, Diastolic, and Mean Blood Pressure; Systemic Vascular Resistance 327 $aLocal Vascular Regulatory MechanismsAutonomic Nervous System Control of Vascular Resistance; Baroreceptors; Baroreceptors and Hypertension; Chemoreceptors and Osmoreceptors; Hypothalamus and Medulla Oblongata and Hypertension; Vasoactive Peptides; The Renin-Angiotensin-Aldosterone System; Endothelin and the Cardiovascular System; Vasopressin and Hypertension; Summary; References; 4: Ion and Fluid Dynamics in Hypertension; Sodium Channels; NHE Transporters; NKCC Transporters; The NCCT; ENaC; Na + /K + ATPase; Calcium Flux; Regulation of Ion Flux; Sodium Distribution and Blood Pressure 327 $aConclusionsReferences; 5: Uric Acid in the Pathogenesis of Hypertension; The History of Uric Acid and Hypertension; Animal Models of Hyperuricemic Hypertension; Epidemiology; Uric Acid Metabolism; Pediatric Clinical Trials; Conclusions; References; 6: Monogenic and Polygenic Contributions to Hypertension; Introduction; Monogenic Forms of Human Hypertension; Glucocorticoid-Remediable Aldosteronism or Familial Hyperaldosteronism Type 1 [OMIM #103900]; Familial Hyperaldosteronism Type 2 OMIM #605635; Familial Hyperaldosteronism Type 3 [OMIM# 613677]: 327 $aApparent Mineralocorticoid Excess [AME] [OMIM # 218030] 330 $aThe field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension. 410 0$aClinical hypertension and vascular diseases. 606 $aHypertension in children 606 $aPediatric cardiology 615 0$aHypertension in children. 615 0$aPediatric cardiology. 676 $a618.92 676 $a618.92132 701 $aFlynn$b Joseph T$01760127 701 $aIngelfinger$b Julie R$01760128 701 $aPortman$b Ronald J$01760129 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910438004303321 996 $aPediatric hypertension$94198944 997 $aUNINA