LEADER 06352nam 22006375 450 001 9910437997203321 005 20200630035146.0 010 $a1-283-94555-X 010 $a3-642-33311-7 024 7 $a10.1007/978-3-642-33311-8 035 $a(CKB)2670000000317376 035 $a(EBL)1082670 035 $a(OCoLC)823735981 035 $a(SSID)ssj0000811899 035 $a(PQKBManifestationID)11528318 035 $a(PQKBTitleCode)TC0000811899 035 $a(PQKBWorkID)10852013 035 $a(PQKB)11427732 035 $a(DE-He213)978-3-642-33311-8 035 $a(MiAaPQ)EBC1082670 035 $a(PPN)168324113 035 $a(EXLCZ)992670000000317376 100 $a20121215d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aStimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve Injury$b[electronic resource] $eFunctional, Electrophysiological and Morphological Proofs /$fby Emmanouil Skouras, Stoyan Pavlov, Habib Bendella, Doychin N. Angelov 205 $a1st ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (122 p.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v213 300 $aDescription based upon print version of record. 311 $a3-642-33310-9 320 $aIncludes bibliographical references and index. 327 $aFirst major set: mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal (clipping) of the contralateral vibrissal hairs.- Second major set: intensive indirect stimulation of the trigeminal afferents after facial nerve surgery by extcision of the contralateral infraorbital nerve -- Third major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by massage of the vibrissal muscles .-  Fourth major set: direct stimulation of the trigeminal and facial nerves after facial nerve surgery by application of  electric current to the vibrissal muscles.- RESULTS.- Mild indirect stimulation of the trigeminal afferents after combined surgery on the infraorbital and facial nerves by removal of the contralateral vibrissal hairs improves vibrissal function.- Intensive indirect stimulation of the trigeminal afferents by excision of the contralateral ION attenuates the degree of collateral axonal branching and improves the accuracy of muscle reinnervation.-   Direct stimulation of the trigeminal and facial nerves by massage of the vibrissal muscles improves the quality of target reinnervation and promotes full recovery of whisking function.- Direct stimulation of the trigeminal and facial nerves by electric current to the vibrissal muscles fails to improve quality of target reinnervation and does not promote recovery of vibrissal function.- DISCUSSION.- Mild indirect stimulation of the trigeminal afferents by removal of the contralateral vibrissal hairs has a beneficial effect on motor recovery.- Beneficial effect of the intensive indirect stimulation of the trigeminal afferents by excision of the contralateral ION.-  Complete recovery of motor function after direct stimulation of the trigeminal and facial nerves by massage of the vibrissal muscles.- Deleterious effect of the direct stimulation of the trigeminal and facial nerves by application of electric current to the vibrissal muscles . - conclusion -- References. 330 $aIts is commonly known that the recovery of mimic functions after facial nerve injury is poor: a successful regrowth of the lesioned axons to their muscle targets is compromised by (i) poor navigation of the growth cones and excessive collateral axonal branching, (ii) abnormal exchange of nerve impulses between adjacent regrowing axons and (iii) insufficient synaptic input to the facial neuronal cell bodies in the brainstem. As a result, axotomized motoneurons become hyperexcitable and unable to discharge. Since the improvement of growth cone navigation and the reduction of the ephaptic cross-talk between axons both turn out be impossible at present, the authors focused their efforts on the third detrimental component and proposed that an intensification of the trigeminal input to the axotomized and electrophysiologically silent facial motoneurons might improve the specificity of reinnervation. To test their hypothesis, they compared behavioral, electrophysiological and morphological parameters after single reconstructive surgery on the facial nerve (or its buccal branch) with those obtained after identical facial nerve surgery but combined with indirect (removal of the contralateral infraorbital nerve, ION) or direct (massage of the mimic muscles) stimulation of the ipsilateral ION. They found that in all cases any trigeminal stimulation was beneficial for the outcome by improving both the quality of target reinnervation (reduced polyinnervation of the motor endplates) and the recovery of vibrissal motor performance (as judged by video-based motion analysis). Based on these results, the authors conclude that trigeminal stimulation is a non-invasive procedure with immediate potential for clinical rehabilitation following facial nerve reconstruction. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x0301-5556 ;$v213 606 $aNeurosciences 606 $aNeurosurgery 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurosurgery$3https://scigraph.springernature.com/ontologies/product-market-codes/H39000 615 0$aNeurosciences. 615 0$aNeurosurgery. 615 14$aNeurosciences. 615 24$aNeurosurgery. 676 $a617.52059 700 $aSkouras$b Emmanouil$4aut$4http://id.loc.gov/vocabulary/relators/aut$0892281 702 $aPavlov$b Stoyan$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aBendella$b Habib$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aAngelov$b Doychin N$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910437997203321 996 $aStimulation of Trigeminal Afferents Improves Motor Recovery After Facial Nerve Injury$91992507 997 $aUNINA