LEADER 03640nam 2200649 a 450 001 9910437992803321 005 20200520144314.0 010 $a1-283-84893-7 010 $a1-4614-4654-6 024 7 $a10.1007/978-1-4614-4654-5 035 $a(CKB)2670000000278752 035 $a(EBL)1030807 035 $a(OCoLC)820022405 035 $a(SSID)ssj0000796509 035 $a(PQKBManifestationID)11413173 035 $a(PQKBTitleCode)TC0000796509 035 $a(PQKBWorkID)10787210 035 $a(PQKB)11679573 035 $a(DE-He213)978-1-4614-4654-5 035 $a(MiAaPQ)EBC1030807 035 $a(PPN)168300842 035 $a(EXLCZ)992670000000278752 100 $a20120924d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNatural products and cancer drug discovery /$fFrank E. Koehn, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (247 p.) 225 0$aCancer drug discovery and development 300 $aDescription based upon print version of record. 311 $a1-4899-9565-X 311 $a1-4614-4653-8 320 $aIncludes bibliographical references and index. 327 $apt. I. Natural product drugs and cancer therapeutics -- pt. II. Advances in natural product cancer drug discovery. 330 $aNatural products- compounds derived from plants, microbes and marine organisms, have been an unsurpassed source of cancer drugs in the modern era of drug discovery.  The historical record is strong, but what is the current impact of natural  products in the discovery and development of cancer drugs, and importantly what are the prospects for natural products to be a valuable source of  future agents?  This volume attempts to address this question through a series of chapters authored by leading researchers in the field which effectively provide an in-depth view of several high impact areas of natural products cancer research. The volume begins with a focused analysis and rationale for the clinical success  of current natural product anti-cancer drugs. The following chapters then describe new natural product based drugs in three rapidly evolving target classes and modalities- agents which target tumor vasculature, inhibitors of histone deacetylase and other histone modifying enzymes, and  antibody drug conjugates.  Subsequent chapters examine the central role of natural product chemical scaffolds in the genesis of new anti-cancer therapeutics- first via the powerful application of chemical synthesis, and then through the  rapidly emerging fields of biosynthetic engineering and plant cell culture.  The volume concludes with an assessment of the critical role that natural products continue to play in the search for new cancer drug targets.  As the reader makes his or her way through the volume it may become clear that there is strong evidence that natural products will continue to exert a profound positive impact on cancer drug discovery. 410 0$aCancer Drug Discovery and Development,$x2196-9906 606 $aDrugs$xResearch 606 $aDrug development 606 $aDrugs$xDesign 615 0$aDrugs$xResearch. 615 0$aDrug development. 615 0$aDrugs$xDesign. 676 $a616.99 676 $a616.99/406 676 $a616.99406 701 $aKoehn$b Frank E$01759390 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437992803321 996 $aNatural products and cancer drug discovery$94197831 997 $aUNINA