LEADER 03393nam 2200649 a 450 001 9910437992603321 005 20200520144314.0 010 $a1-283-93366-7 010 $a1-4614-4741-0 024 7 $a10.1007/978-1-4614-4741-2 035 $a(CKB)3400000000093719 035 $a(EBL)1081854 035 $a(OCoLC)822995930 035 $a(SSID)ssj0000810373 035 $a(PQKBManifestationID)11494962 035 $a(PQKBTitleCode)TC0000810373 035 $a(PQKBWorkID)10846306 035 $a(PQKB)11322690 035 $a(DE-He213)978-1-4614-4741-2 035 $a(MiAaPQ)EBC1081854 035 $a(PPN)168301083 035 $a(EXLCZ)993400000000093719 100 $a20121018d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvances in DNA repair in cancer therapy /$fLawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (316 p.) 225 0$aCancer drug discovery and development 300 $aDescription based upon print version of record. 311 $a1-4899-9308-8 311 $a1-4614-4740-2 320 $aIncludes bibliographical references and index. 327 $aPreface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index. 330 $aThis book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin.  The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1.  Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling  is examined. 410 0$aCancer Drug Discovery and Development,$x2196-9906 606 $aCancer$xTreatment$xGenetic aspects 606 $aDNA repair 615 0$aCancer$xTreatment$xGenetic aspects. 615 0$aDNA repair. 676 $a616.99 676 $a616.99/4061 676 $a616.99406 701 $aPanasci$b Lawrence$01755709 701 $aAloyz$b Raquel$01755710 701 $aAlaoui-Jamali$b Moulay$01755711 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437992603321 996 $aAdvances in DNA repair in cancer therapy$94192614 997 $aUNINA