LEADER 04110nam 2200601 a 450 001 9910437857203321 005 20200520144314.0 010 $a1-4614-4744-5 024 7 $a10.1007/978-1-4614-4744-3 035 $a(CKB)2670000000277906 035 $a(EBL)1030855 035 $a(OCoLC)818827910 035 $a(SSID)ssj0000799121 035 $a(PQKBManifestationID)11462981 035 $a(PQKBTitleCode)TC0000799121 035 $a(PQKBWorkID)10762910 035 $a(PQKB)11626158 035 $a(DE-He213)978-1-4614-4744-3 035 $a(MiAaPQ)EBC1030855 035 $a(PPN)168301091 035 $a(EXLCZ)992670000000277906 100 $a20120907d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRNA interference from biology to therapeutics /$fKenneth A. Howard, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (347 p.) 225 0$aAdvances in delivery science and technology,$x2192-6204 300 $aDescription based upon print version of record. 311 $a1-4899-9319-3 311 $a1-4614-4743-7 320 $aIncludes bibliographical references and index. 327 $aRNA Interference Pathways and Therapeutic Exploitation RNA Interference -- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference -- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine -- Intracellular Delivery Considerations for RNAi Therapeutics -- Mucosal Delivery of RNAi Therapeutics -- Nanomedicines for Systemic Delivery of RNAi Therapeutics -- Lipidoids: A Combinatorial Approach to siRNA Delivery -- Polymeric Micelles for siRNA Delivery -- RNAi Therapeutic Delivery by Exosomes -- Aptamer-Mediated siRNA Targeting -- RNAi as Anti-Viral Therapy: The HIV-1 Case -- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication -- The Application of microRNAs in Cancer Diagnostics -- Therapeutic Application of miRNAs in Cancer -- Clinical Development of an Inhalable Anti-RSV siRNA Treatment. 330 $aThe Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.   Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of ?RNA Interference from Biology to Therapeutics? that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a ?must-read? for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the ?future perspectives? section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. ?RNA Interference from Biology to Therapeutics? is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field. 410 0$aAdvances in Delivery Science and Technology,$x2192-6204 606 $aRNA editing 606 $aGene silencing 615 0$aRNA editing. 615 0$aGene silencing. 676 $a572.88 686 $aWC 4460$2rvk 701 $aHoward$b Kenneth A$0111144 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437857203321 996 $aRNA interference from biology to therapeutics$94202748 997 $aUNINA