LEADER 04117nam 22006135 450 001 9910437856203321 005 20200705074707.0 010 $a1-4614-8232-1 024 7 $a10.1007/978-1-4614-8232-1 035 $a(CKB)3710000000019046 035 $a(EBL)1466728 035 $a(SSID)ssj0001004909 035 $a(PQKBManifestationID)11582245 035 $a(PQKBTitleCode)TC0001004909 035 $a(PQKBWorkID)11051847 035 $a(PQKB)11617994 035 $a(DE-He213)978-1-4614-8232-1 035 $a(MiAaPQ)EBC1466728 035 $a(PPN)17242089X 035 $a(EXLCZ)993710000000019046 100 $a20130913d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye /$fedited by Amit Singh, Madhuri Kango-Singh 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (375 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-8231-3 320 $aIncludes bibliographical references and index. 327 $aEarly eye development: Specification and Determination -- Molecular genetic mechanisms of axial patterning: Mechanistic insights into generation of axes in the developing eye -- Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow -- Cell Morphogenesis -- Cell Polarity in Drosophila Retina -- Negative regulation for neural patterning in the Drosophila eye -- Cell Adhesion during Drosophila eye development -- Modulation of Developmental Signaling by the Proteostasis Network -- Drosophila eye as a model to study regulation of growth control: The discovery of size control pathways -- Contribution of the Drosophila eye to unraveling the basis of neurodegeneration -- Genetic regulation of early eye development in non-dipteran insects -- Development and evolution of the Drosophila Bolwig?s organ: a compound eye relict -- Index. 330 $aUndoubtedly, Drosophila melanogaster, fruit fly, has proven to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases.  One of the most important questions in biology focuses on: how does a multi-cellular organism develop from a single-celled embryo? The discovery of the genes responsible for pattern formation has helped refine this question.  Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, axial patterning, growth regulation in Drosophila eye, and more. 606 $aHuman genetics 606 $aAnimal models in research 606 $aMedicine 606 $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aHuman genetics. 615 0$aAnimal models in research. 615 0$aMedicine. 615 14$aHuman Genetics. 615 24$aAnimal Models. 615 24$aBiomedicine, general. 676 $a595.774 702 $aSingh$b Amit$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKango-Singh$b Madhuri$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437856203321 996 $aMolecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye$92542167 997 $aUNINA