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010   $a9783642259500
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024 7 $a10.1007/978-3-642-25950-0
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035   $a(PQKBTitleCode)TC0000906497
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035   $a(DE-He213)978-3-642-25950-0
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100   $a20130325d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aCircadian clocks /$fAchim Kramer, Martha Merrow, editors
205   $a1st ed. 2013.
210   $aHoboken, N.J. $cSpringer$d2013
215   $a1 online resource (417 p.)
225 1 $aHandbook of Experimental Pharmacology,$x0171-2004 ;$v217
300   $aDescription based upon print version of record.
311 08$a9783642448539 
311 08$a3642448534 
311 08$a9783642259494 
311 08$a3642259499 
320   $aIncludes biliographical references and index.
327   $aPart I. Molecular and cellular basis of circadian clocks. Molecular components of the mammalian circadian clock. The epigenetic language of circadian clocks. Peripheral circadian oscillators in mammals. Cellular mechanisms of circadian pacemaking: beyond transcriptional loops. The clock in the brain: Neurons, glia and networks in daily rhythms -- Part II. Circadian control of physiology and behavior. Circadian clocks and metabolism. The circadian control of sleep. Daily regulation of hormone profiles. Circadian clocks and mood-related behaviors. Part III. Chronopharmacology and chronotherapy. Molecular Clocks in Pharmacology. Cancer chronotherapeutics: Experimental, theoretical and clinical aspects. Pharmacological modulators of the circadian clock as potential therapeutic drugs: Focus on genotoxic/anticancer therapy. Light and the human circadian clock -- Part IV. Systems biology of circadian clocks. Mathematical modeling in chronobiology. Mammalian circadian clock: the roles of transcriptional repression and delay. Genome-wide analyses of circadian systems. Proteomic approaches in circadian biology.
330   $aThis book provides the reader with a contemporary and comprehensive overview about the molecular, cellular and system-wide principles of circadian clock regulation. Emphasis is placed on the importance of circadian clocks for the timing of therapeutic interventions.
410  0$aHandbook of Experimental Pharmacology,$x0171-2004 ;$v217
606   $aCircadian rhythms
606   $aChronobiology
615  0$aCircadian rhythms.
615  0$aChronobiology.
676   $a571.77
701   $aKra?mer$b Achim$f1939-$01751932
701   $aMerrow$b Martha$01751933
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437852903321
996   $aCircadian clocks$94187074
997   $aUNINA