LEADER 03295nam 2200577Ia 450 001 9910437851303321 005 20200520144314.0 010 $a1-299-33660-4 010 $a1-4614-6144-8 024 7 $a10.1007/978-1-4614-6144-9 035 $a(CKB)2670000000336366 035 $a(EBL)1082091 035 $a(OCoLC)828794642 035 $a(SSID)ssj0000879033 035 $a(PQKBManifestationID)11477717 035 $a(PQKBTitleCode)TC0000879033 035 $a(PQKBWorkID)10836462 035 $a(PQKB)10573664 035 $a(DE-He213)978-1-4614-6144-9 035 $a(MiAaPQ)EBC1082091 035 $a(PPN)168304783 035 $a(EXLCZ)992670000000336366 100 $a20130217d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aHeart valves $efrom design to clinical implantation /$fPaul A. Iaizzo ...[et. al.], editors 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (429 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-9614-1 311 $a1-4614-6143-X 320 $aIncludes bibliographical references and index. 327 $aPart I - ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE -- The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Part II - VALVE REPAIR AND REPLACEMENT -- History of heart valve repair -- Heart valve disease -- Advanced 3D imaging and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Tissue engineered heart valves -- Part III - TESTING AND REGULATORY ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Index. 330 $aCardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications. 606 $aHeart valves 606 $aHeart$xSurgery 615 0$aHeart valves. 615 0$aHeart$xSurgery. 676 $a617.4120592 701 $aIaizzo$b Paul A$01368668 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437851303321 996 $aHeart valves$94195744 997 $aUNINA