LEADER 03629nam 2200577Ia 450 001 9910437850803321 005 20200520144314.0 010 $a1-283-84894-5 010 $a1-4614-4666-X 024 7 $a10.1007/978-1-4614-4666-8 035 $a(CKB)2670000000279087 035 $a(EBL)1030808 035 $a(OCoLC)824487129 035 $a(SSID)ssj0000789319 035 $a(PQKBManifestationID)11413147 035 $a(PQKBTitleCode)TC0000789319 035 $a(PQKBWorkID)10726479 035 $a(PQKB)10636383 035 $a(DE-He213)978-1-4614-4666-8 035 $a(MiAaPQ)EBC1030808 035 $a(PPN)168300877 035 $a(EXLCZ)992670000000279087 100 $a20121211d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvances in biology and therapy of multiple myeloma$hVolume 1$iBasic science /$fNikhil C. Munshi, Kenneth C. Anderson, editors 210 $aNew York $cSpringer$dc2013 215 $a1 online resource (321 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-4665-1 320 $aIncludes bibliographical references and index. 327 $aGenomic strategies determining progressions from MGUS to Multiple Myeloma -- Prognostic implication of Genetic changes (Cytogenetics, and FISH, gains and losses of DNA by SNP array and aCGH) in risk stratification in myeloma -- Advances in MM gene expression profiling -- Growth factors in MM -- Role of Wnt signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT signaling in the pathogenesis and treatment of multiple myeloma -- Role of extracellular matrix in myeloma biology -- Osteoclasts: Potential target for blocking microenvironmental support of myeloma -- Targeting the BAFF/APRIL cytokine network in multiple myeloma -- Role of Osteoblast in myeloma pathology -- Migration and homing in Multiple Myeloma -- Genes and proteins of myeloma endothelial cells to search specific targets of the tumor vasculature -- Epigenetic regulation of myeloma within its bone marrow microenvironment -- Targeting mulitple myeloma tumor angiogenesis: focus on VEGF -- Novel in vivo model in myeloma -- Index. 330 $aDespite the advances in conventional, and novel agent and high dose chemotherapy, multiple myeloma remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in multiple myeloma focusing on the development of molecularly-based novel targeted single-agent and combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.   This volume will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways and intermediate molecules that are being investigated for development of novel therapies. The book will present newer developments, providing an emphasis on basic science, as well as its significant clinical impact. 606 $aBone marrow$xDiseases 606 $aMyelodysplastic syndromes 615 0$aBone marrow$xDiseases. 615 0$aMyelodysplastic syndromes. 676 $a616.99/418 676 $a616.9941806 701 $aMunshi$b Nikhil C$01064467 701 $aAnderson$b Kenneth C$0876632 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437850803321 996 $aAdvances in biology and therapy of multiple myeloma$92538380 997 $aUNINA