LEADER 03664nam 2200577Ia 450 001 9910437849303321 005 20200520144314.0 010 $a1-299-40862-1 010 $a94-007-5842-1 024 7 $a10.1007/978-94-007-5842-1 035 $a(CKB)2670000000338260 035 $a(EBL)1083662 035 $a(OCoLC)828302725 035 $a(SSID)ssj0000870680 035 $a(PQKBManifestationID)11474727 035 $a(PQKBTitleCode)TC0000870680 035 $a(PQKBWorkID)10818743 035 $a(PQKB)10841237 035 $a(DE-He213)978-94-007-5842-1 035 $a(MiAaPQ)EBC1083662 035 $a(PPN)168341905 035 $a(EXLCZ)992670000000338260 100 $a20121219h20132013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCancer genomics $emolecular classification, prognosis and response prediction /$fUlrich Pfeffer, editor 205 $a1st ed. 2013. 210 $aDordrecht $cSpringer$dc2013 215 $a1 online resource (590 p.) 300 $aDescription based upon print version of record. 311 $a94-007-9802-4 311 $a94-007-5841-3 320 $aIncludes bibliographical references and index. 327 $aPreface -- Genomic Pathology of Lung Cancer -- Understanding Melanoma Progression by Gene Expression Signatures -- Prognostic testing in uveal melanoma -- Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer -- Predictive and Prognostic Biomarkers for Colorectal Cancer -- Expression Profiling of Hepatocellular Carcinoma -- Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine -- 8 Pancreatic cancer genomics -- Breast Cancer Genomics: From Portraits to Landscapes -- Genomic landscape of ovarian cancer -- Genetics of Endometrial Carcinoma -- Usefulness of molecular biology in follicular-derived thyroid tumors - From translationnal research to clinical practice -- Sarcomas Genetics: From point mutation to complex karyotype, from diagnosis to therapies -- Novel molecular acquisitions in leukemias -- Where do we stand in the genomics of lymphomas?- The Genomics of Multiple Myeloma and Its Relevance in the Molecular Classification and Risk Stratification of the Disease -- Index. 330 $aThe combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident. . 606 $aCancer$xGenetic aspects 606 $aGenomics 615 0$aCancer$xGenetic aspects. 615 0$aGenomics. 676 $a616.994042 701 $aPfeffer$b Ulrich$0798794 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437849303321 996 $aCancer genomics$94186542 997 $aUNINA