LEADER 04615nam 22007455 450 001 9910437849303321 005 20200702003907.0 010 $a1-299-40862-1 010 $a94-007-5842-1 024 7 $a10.1007/978-94-007-5842-1 035 $a(CKB)2670000000338260 035 $a(EBL)1083662 035 $a(OCoLC)828302725 035 $a(SSID)ssj0000870680 035 $a(PQKBManifestationID)11474727 035 $a(PQKBTitleCode)TC0000870680 035 $a(PQKBWorkID)10818743 035 $a(PQKB)10841237 035 $a(DE-He213)978-94-007-5842-1 035 $a(MiAaPQ)EBC1083662 035 $a(PPN)168341905 035 $a(EXLCZ)992670000000338260 100 $a20130217d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCancer Genomics$b[electronic resource] $eMolecular Classification, Prognosis and Response Prediction /$fedited by Ulrich Pfeffer 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (590 p.) 300 $aDescription based upon print version of record. 311 $a94-007-9802-4 311 $a94-007-5841-3 320 $aIncludes bibliographical references and index. 327 $aPreface -- Genomic Pathology of Lung Cancer -- Understanding Melanoma Progression by Gene Expression Signatures -- Prognostic testing in uveal melanoma -- Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer -- Predictive and Prognostic Biomarkers for Colorectal Cancer -- Expression Profiling of Hepatocellular Carcinoma -- Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine -- 8 Pancreatic cancer genomics -- Breast Cancer Genomics: From Portraits to Landscapes -- Genomic landscape of ovarian cancer -- Genetics of Endometrial Carcinoma -- Usefulness of molecular biology in follicular-derived thyroid tumors - From translationnal research to clinical practice -- Sarcomas Genetics: From point mutation to complex karyotype, from diagnosis to therapies -- Novel molecular acquisitions in leukemias -- Where do we stand in the genomics of lymphomas?- The Genomics of Multiple Myeloma and Its Relevance in the Molecular Classification and Risk Stratification of the Disease -- Index. 330 $aThe combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident. . 606 $aCancer research 606 $aGene expression 606 $aMicroarrays 606 $aMolecular biology 606 $aMedicine 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aGene Expression$3https://scigraph.springernature.com/ontologies/product-market-codes/B12010 606 $aMicroarrays$3https://scigraph.springernature.com/ontologies/product-market-codes/B12050 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 615 0$aCancer research. 615 0$aGene expression. 615 0$aMicroarrays. 615 0$aMolecular biology. 615 0$aMedicine. 615 14$aCancer Research. 615 24$aGene Expression. 615 24$aMicroarrays. 615 24$aMolecular Medicine. 615 24$aBiomedicine, general. 676 $a616.994042 676 $a616.99404227 702 $aPfeffer$b Ulrich$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437849303321 996 $aCancer Genomics$92542161 997 $aUNINA