LEADER 03788nam 22006495 450 001 9910437848803321 005 20200705232145.0 010 $a1-283-93403-5 010 $a1-4614-5326-7 024 7 $a10.1007/978-1-4614-5326-0 035 $a(CKB)3400000000093744 035 $a(EBL)1081895 035 $a(OCoLC)822579077 035 $a(SSID)ssj0000811443 035 $a(PQKBManifestationID)11495118 035 $a(PQKBTitleCode)TC0000811443 035 $a(PQKBWorkID)10850963 035 $a(PQKB)11612644 035 $a(DE-He213)978-1-4614-5326-0 035 $a(MiAaPQ)EBC1081895 035 $a(PPN)168302721 035 $a(EXLCZ)993400000000093744 100 $a20121206d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMucosal Immunology of Acute Bacterial Pneumonia$b[electronic resource] /$fedited by Alice Prince 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (285 p.) 300 $aDescription based upon print version of record. 311 $a1-4899-9035-6 311 $a1-4614-5325-9 320 $aIncludes bibliographical references and index. 327 $aAlveolar macrophages ? key coordinators of host defense -- Lung dendritic cells and pulmonary defense mechanisms against bacteria -- CD4 T cell immunity in the lung -- Neutrophil mediated defenses in bacterial pneumonia -- Toll-like receptors in the epithelium -- Type I IFN signaling in bacterial pneumonia -- Transcriptional signaling hubs in epithelial cells during pneumonia.- Innate immune responses in Ventilator Associated Pneumonia -- Streptococcus pneumoniae: The prototype of lung responses in pneumonia -- Staphylococcus aureus infection of the respiratory tract -- Pseudomonas aeruginosa: the consummate opportunistic pathogen of the lung.  . 330 $aIn contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens.  The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections.  It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae.   By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic. 606 $aImmunology 606 $aMedical microbiology 606 $aInfectious diseases 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 615 0$aImmunology. 615 0$aMedical microbiology. 615 0$aInfectious diseases. 615 14$aImmunology. 615 24$aMedical Microbiology. 615 24$aInfectious Diseases. 676 $a616.2 676 $a616.241 702 $aPrince$b Alice$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437848803321 996 $aMucosal Immunology of Acute Bacterial Pneumonia$92502977 997 $aUNINA