LEADER 04074nam 22006975 450 001 9910437844803321 005 20200707012223.0 010 $a1-4614-8412-X 024 7 $a10.1007/978-1-4614-8412-7 035 $a(CKB)3710000000024292 035 $a(EBL)1466357 035 $a(OCoLC)861080764 035 $a(SSID)ssj0001049027 035 $a(PQKBManifestationID)11652469 035 $a(PQKBTitleCode)TC0001049027 035 $a(PQKBWorkID)11018469 035 $a(PQKB)10259651 035 $a(DE-He213)978-1-4614-8412-7 035 $a(MiAaPQ)EBC1466357 035 $a(PPN)176098763 035 $a(EXLCZ)993710000000024292 100 $a20131002d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aMolecular Pathogenesis of Colorectal Cancer /$fedited by Kevin M. Haigis, Ph.D 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (319 p.) 300 $aDescription based upon print version of record. 311 $a1-4614-8411-1 320 $aIncludes bibliographical references and index. 327 $aPreface -- The Genetics of Colorectal Cancer -- Molecular Mechanisms of Colorectal Carcinogenesis -- The association between inflammation and colorectal cancer -- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease -- Mutational activation of KRAS and BRAF in colorectal cancer -- The PI3K pathway in Colorectal Cancers -- TGF-ß signaling pathway and colorectal cancer -- The Clinical Significance of Mutations in Colorectal Cancer -- Colorectal Cancer Genome and Its Implications -- Copy-Number Alterations in the Colorectal Cancer Genome -- Genome-wide association studies in colorectal cancer -- Future prospects for leveraging molecular information in the fight against colorectal cancer -- Index. 330 $aFor more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression. 606 $aCancer$xResearch 606 $aMolecular biology 606 $aProteins 606 $aCytology 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aCancer$xResearch. 615 0$aMolecular biology. 615 0$aProteins. 615 0$aCytology. 615 14$aCancer Research. 615 24$aMolecular Medicine. 615 24$aProtein Science. 615 24$aCell Biology. 676 $a571.6 676 $a572.6 676 $a610 676 $a611.01816 702 $aHaigis$b Ph.D., Kevin M$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437844803321 996 $aMolecular Pathogenesis of Colorectal Cancer$92510112 997 $aUNINA