LEADER 03962nam 2200697Ia 450 001 9910437843303321 005 20200520144314.0 010 $a1-283-93385-3 010 $a1-4614-5070-5 024 7 $a10.1007/978-1-4614-5070-2 035 $a(CKB)3400000000093730 035 $a(EBL)1030889 035 $a(OCoLC)822030021 035 $a(SSID)ssj0000879083 035 $a(PQKBManifestationID)11475041 035 $a(PQKBTitleCode)TC0000879083 035 $a(PQKBWorkID)10850874 035 $a(PQKB)10008572 035 $a(DE-He213)978-1-4614-5070-2 035 $a(MiAaPQ)EBC1030889 035 $a(iGPub)SPNA0022291 035 $a(PPN)168301954 035 $a(EXLCZ)993400000000093730 100 $a20121102d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aImmunomic discovery of adjuvants and candidate subunit vaccines /$fDarren R. Flower, Yvonne Perrie, editors 205 $a1st ed. 2013. 210 $aNew York ;$aLondon $cSpringer$d2013 215 $a1 online resource (315 p.) 225 0 $aImmunomics reviews ;$v5 300 $aDescription based upon print version of record. 311 $a1-4899-9795-4 311 $a1-4614-5069-1 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Bacterial genomes and vaccine design -- Identification of candidate vaccine antigens in silico -- Post-Genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T-Cell Antigens of Mycobacterium Bovis -- Genome-based Computational Vaccine Discovery by Reverse Vaccinology -- Computational prediction of protein subcellular localization, genomic islands, and virulence to aid antigen discovery -- On the development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge -- What have Dendritic Cells ever done for adjuvant design?  Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants -- Towards the Rational Discovery of Adjuvants -- Designing liposomes as vaccine adjuvants -- Enhancing the delivery and potency of antigens using non-ionic based vesicles -- Immune stimulating complexes (ISCOMs) and Quil-A containing particulate formulations as vaccine delivery systems -- Formulation and characterisation of PLGA microspheres as vaccine adjuvants -- Powder Vaccines for Pulmonary Delivery. 330 $aVaccine discovery is one of the most exciting and fast-moving areas of applied science. Since Edward Jenner?s work in the 18th century, vaccines have transformed health across the globe. Bringing together clinical, experimental, and computational disciplines vaccinology addresses the most pressing needs of 21st century health-care: the great infectious diseases threatening the developing world, such as HIV, Malaria, and TB; and chronic diseases, such as dementia, threatening the developed world. This volume seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology. 410 0$aImmunomics Reviews:, An Official Publication of the International Immunomics Society,$x2628-5789 ;$v5 606 $aVaccines 606 $aImmunological adjuvants 606 $aAntigens 606 $aVaccines$xDesign$xHistory 615 0$aVaccines. 615 0$aImmunological adjuvants. 615 0$aAntigens. 615 0$aVaccines$xDesign$xHistory. 676 $a615.372 686 $aVS 9000$2rvk 686 $aXD 3311$2rvk 701 $aFlower$b Darren R$0472707 701 $aPerrie$b Yvonne$01755752 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437843303321 996 $aImmunomic discovery of adjuvants and candidate subunit vaccines$94192652 997 $aUNINA