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100   $a20131008d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aGadd45 Stress Sensor Genes /$fedited by Dan A. Liebermann, Barbara Hoffman
205   $a1st ed. 2013.
210  1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013.
215   $a1 online resource (141 p.)
225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v793
300   $aDescription based upon print version of record.
311   $a1-4614-8288-7 
320   $aIncludes bibliographical references and index.
327   $aGadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver ? Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index.
330   $aEmerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  .
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v793
606   $aMedical genetics
606   $aBiochemistry
606   $aHuman genetics
606   $aGene Function$3https://scigraph.springernature.com/ontologies/product-market-codes/B12030
606   $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005
606   $aHuman Genetics$3https://scigraph.springernature.com/ontologies/product-market-codes/B12008
615  0$aMedical genetics.
615  0$aBiochemistry.
615  0$aHuman genetics.
615 14$aGene Function.
615 24$aBiochemistry, general.
615 24$aHuman Genetics.
676   $a572
702   $aLiebermann$b Dan A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aHoffman$b Barbara$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910437840803321
996   $aGadd45 Stress Sensor Genes$92510105
997   $aUNINA