LEADER 04500nam 22007935 450 001 9910437839103321 005 20200630144236.0 010 $a94-007-5808-1 024 7 $a10.1007/978-94-007-5808-7 035 $a(CKB)2670000000328611 035 $a(EBL)1083652 035 $a(OCoLC)826009052 035 $a(SSID)ssj0000878604 035 $a(PQKBManifestationID)11560802 035 $a(PQKBTitleCode)TC0000878604 035 $a(PQKBWorkID)10837163 035 $a(PQKB)11619266 035 $a(DE-He213)978-94-007-5808-7 035 $a(MiAaPQ)EBC1083652 035 $a(PPN)168341824 035 $a(EXLCZ)992670000000328611 100 $a20130125d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCilia and Nervous System Development and Function$b[electronic resource] /$fedited by Kerry L. Tucker, Tamara Caspary 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (285 p.) 300 $aDescription based upon print version of record. 311 $a94-017-8295-4 311 $a94-007-5807-3 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- 1 Primary and motile cilia: their ultrastructure and ciliogenesis -- 2 Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord Development -- 3 Primary cilia and brain development -- 4 Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-Neuronal Cells -- 5 Primary Cilia and Inner Ear Sensory Epithelia -- 6 Neuronal Cilia and Obesity -- 7 Motile cilia and brain function: ependymal motile cilia development, organization, function and their associated pathologies -- 8 Primary Cilia and Brain Cancer -- 9 Abnormalities of the Central Nervous System across the Ciliopathy Spectrum. 330 $aCilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and  process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function. 606 $aMedicine 606 $aNeurobiology 606 $aNeurosciences 606 $aHuman physiology 606 $aCancer research 606 $aDevelopmental biology 606 $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X 606 $aNeurobiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L25066 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aDevelopmental Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18000 615 0$aMedicine. 615 0$aNeurobiology. 615 0$aNeurosciences. 615 0$aHuman physiology. 615 0$aCancer research. 615 0$aDevelopmental biology. 615 14$aBiomedicine, general. 615 24$aNeurobiology. 615 24$aNeurosciences. 615 24$aHuman Physiology. 615 24$aCancer Research. 615 24$aDevelopmental Biology. 676 $a612.81046 700 $aTucker$b Kerry L$01243987 702 $aTucker$b Kerry L$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCaspary$b Tamara$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437839103321 996 $aCilia and Nervous System Development and Function$92885458 997 $aUNINA