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024 7 $a10.1007/978-1-4614-6111-1
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035   $a(EBL)1082085
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035   $a(DE-He213)978-1-4614-6111-1
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100   $a20130401d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 04$aThe New paradigm of immunity to tuberculosis /$fMaziar Divangahi, editor
205   $a1st ed. 2013.
210   $aNew York $cSpringer$dc2013
215   $a1 online resource (294 p.)
225 0 $aAdvances in experimental medicine and biology ;$vv.783
300   $aDescription based upon print version of record.
311   $a1-4899-9063-1 
311   $a1-4614-6110-3 
320   $aIncludes bibliographical references and index.
327   $aEpidemiology of tuberculosis immunology -- Host pathogen specificity in tuberculosis -- Genetic determinants of susceptibility to mycobacterial infections -- Evolution of mycobacterium tuberculosis -- Mycobacterium tuberculosis genes involved in regulation of host cell death -- Dying to live: how the death modality of the infected macrophage affects immunity to tuberculosis -- Cytokines in the balance of protection and pathology during mycobactyerial infections -- Antigen-specific CD8+ T cells and protective immunity to tuberculosis -- Foxp3+ regulatory T cells in tuberculosis -- CD1a, CD1b, and CD1c in immunity against mycobacteria -- CD1d and natural killer T cells in immunity to mycobacterium tuberculosis -- The role of B cells and humoral immunity in mycobacterium tuberculosis infection -- Looking within the zebrafish to understand the tuberculosis granuloma -- Immunization strategies against pulmonary tuberculosis: Considerations of T cell geography.
330   $aThis book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former?s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors? recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.
410  0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v783
606   $aTuberculosis$xImmunological aspects
606   $aTuberculosis$xVaccination
615  0$aTuberculosis$xImmunological aspects.
615  0$aTuberculosis$xVaccination.
676   $a616.9
676   $a616.995
701   $aDivangahi$b Maziar$01287917
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437838803321
996   $aThe New paradigm of immunity to tuberculosis$94204705
997   $aUNINA