LEADER 04516nam 22006615 450 001 9910437837503321 005 20200706023130.0 010 $a94-007-7835-X 024 7 $a10.1007/978-94-007-7835-1 035 $a(CKB)3710000000075904 035 $a(EBL)1592464 035 $a(SSID)ssj0001086261 035 $a(PQKBManifestationID)11679948 035 $a(PQKBTitleCode)TC0001086261 035 $a(PQKBWorkID)11055359 035 $a(PQKB)11418470 035 $a(DE-He213)978-94-007-7835-1 035 $a(MiAaPQ)EBC1592464 035 $a(PPN)176130306 035 $a(EXLCZ)993710000000075904 100 $a20131202d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aExperimental Metastasis: Modeling and Analysis /$fedited by Anastasia Malek 205 $a1st ed. 2013. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2013. 215 $a1 online resource (212 p.) 300 $aDescription based upon print version of record. 311 $a94-007-7834-1 320 $aIncludes bibliographical references and index. 327 $aPreface -- Introduction -- Head and neck cancer -- Breast cancer invasion and metastasis -- Mouse models of pancreatic cancer -- Brain Metastasis -- Lung metastasis -- Liver Metastases -- Malignant pleural effusion -- Mathematic modeling of metastatic process. Index. 330 $aMetastatic dissemination remains a main cause for cancer related deaths. Investigation of the molecular mechanisms of the metastatic process presents an important area of cancer research and may provide clinical oncologists with new methods to prevent and manage cancer dissemination. Availability of adequate experimental models is an essential requirement of the productive investigation. Over the many years of cancer research, plenty of model systems (in vitro and in vivo) were created to reproduce certain steps or to estimate certain aspects of metastatic process. Currently right selection and correct application of the experimental models as well as analytic technique may present a challenge. This book provide with guideline information about experimental modelling and analysis of the metastatic process. The structure of the book reflects clinical aspects: pathway and area of the metastatic dissemination. Thus, first part of book is devoted to local, mainly via lymph system, spread of head and neck, breast and pancreatic cancers. Second part is about distant, via blood stream, dissemination into brain and lung (most often sites of metastatic lesion regardless the primary tumour issue). Third part includes chapter describing methods of modelling and study specific metastatic pathways: via portal vein system and through serous cavities. Any chapter is introduced by short review of clinical/biological aspects of the specific metastatic process, provides with description of relevant laboratory techniques, supplemented with representative illustrations and extended references list. Theoretic aspects of cancer dissemination and mathematic approaches to model metastatic spread of tumour are reviewed in the last chapter. Chapters of the book are written by leading specialists in certain areas of metastatic cancer research, therefore the book presents a comprehensive guide for researchers and may be helpful for clinical oncologists. 606 $aCancer$xResearch 606 $aDiagnosis, Laboratory 606 $aAnimal models in research 606 $aCell culture 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aLaboratory Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B15007 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 606 $aCell Culture$3https://scigraph.springernature.com/ontologies/product-market-codes/L16020 615 0$aCancer$xResearch. 615 0$aDiagnosis, Laboratory. 615 0$aAnimal models in research. 615 0$aCell culture. 615 14$aCancer Research. 615 24$aLaboratory Medicine. 615 24$aAnimal Models. 615 24$aCell Culture. 676 $a571.638 676 $a616.99407 702 $aMalek$b Anastasia$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437837503321 996 $aExperimental Metastasis: Modeling and Analysis$92502963 997 $aUNINA