LEADER 05799nam 22006975 450 001 9910437837103321 005 20200704034340.0 010 $a1-4614-8978-4 024 7 $a10.1007/978-1-4614-8978-8 035 $a(CKB)3710000000024311 035 $a(EBL)1466420 035 $a(OCoLC)861080701 035 $a(SSID)ssj0001049055 035 $a(PQKBManifestationID)11599470 035 $a(PQKBTitleCode)TC0001049055 035 $a(PQKBWorkID)11015082 035 $a(PQKB)11782147 035 $a(DE-He213)978-1-4614-8978-8 035 $a(MiAaPQ)EBC1466420 035 $a(PPN)176100202 035 $a(EXLCZ)993710000000024311 100 $a20131001d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTestosterone: From Basic Research to Clinical Applications /$fby Lee B. Smith, Rod T. Mitchell, Iain J. McEwan 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (78 p.) 225 1 $aSpringerBriefs in Reproductive Biology,$x2194-4253 300 $aDescription based upon print version of record. 311 $a1-4614-8977-6 327 $a""Preface""; ""Contents""; ""Abstract""; ""1 History of Masculinization""; ""1.1a???From the Ancient World to the Nineteenth Century""; ""1.2a???a???Cell Therapya??? or the Search for a???The Fountain of Youtha???""; ""1.3a???Steroid Hunters""; ""1.4a???Dihydrotestosterone a Potent Androgen""; ""1.5a???Receptor Model for Steroid Hormone Action""; ""1.6a???Key Points-Summary""; ""References""; ""2 Recent Understanding of Masculinization""; ""2.1a???The History of Masculinization""; ""2.2a???The Ontogeny of Testicular Development"" 327 $a""2.3a???Human Conditions Associated with Androgen Disruption During Development""""2.4a???The Universal Male Programming Window""; ""2.5a???Key Points-Summary""; ""References""; ""3 Where Does Testosterone Come from and How Does It Act?""; ""3.1a???Testes-Cellular Morphology""; ""3.2a???Steroidogenesis""; ""3.3a???Adrenal Gland""; ""3.4a???Ovary""; ""3.5a???The Androgen Receptor (NR3C4)""; ""3.5.1 Ligand Binding Domain""; ""3.5.2 DNA Binding Domain/Hinge Region""; ""3.5.3 N-Terminal Domain""; ""3.6a???Rapid Signaling by Testosterone""; ""3.7a???Key Points-Summary""; ""References"" 327 $a""4 Androgen Receptor Signaling in the Testis""""4.1a???Introduction""; ""4.2a???Tfm ARKO Mouse""; ""4.3a???The Cre/Lox System""; ""4.4a???Cell-Specific KO""; ""4.5a???AR in Sertoli Cells""; ""4.6a???AR in Peritubular Myoid Cells""; ""4.7a???AR in Leydig Cells""; ""4.8a???Key Points-Summary""; ""References""; ""5 Androgen Signaling in Other Body Systems""; ""5.1a???Seminal Vesicles""; ""5.2a???Epididymis""; ""5.3a???Prostate""; ""5.3.1 Androgens and Prostate Gland Development""; ""5.3.2 Prostate Cancer""; ""5.4a???Muscle and Bone""; ""5.4.1 Bone""; ""5.4.2 Muscle Cells"" 327 $a""5.4.3 Spinal Bulbular Muscular Dystrophy (SBMA Kennedya???s Disease)""; ""5.5a???Cardiovascular Role of Testosterone""; ""5.6a???Female Reproductive System""; ""5.6.1 Breast""; ""5.6.2 Endometrium""; ""5.7a???Key Points-Summary""; ""References""; ""6 Manipulating Androgens for Therapy""; ""6.1a???Management of DSD""; ""6.1.1 Congenital Adrenal Hyperplasia""; ""6.1.2 Androgen Insensitivity Syndrome""; ""6.1.3 5 alpha -Reductase Deficiency""; ""6.2a???Delayed Puberty and Pubertal Induction""; ""6.3a???Fertility Induction""; ""6.4a???Erectile Dysfunction"" 327 $a""6.5a???Testosterone in the Aging Male: The a???Andropausea???""""6.6a???Polycystic Ovarian Syndrome (PCOS)""; ""6.7a???Key Points""; ""References""; ""Epilogue Future Perspectives "" 330 $aThis volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit. 410 0$aSpringerBriefs in Reproductive Biology,$x2194-4253 606 $aReproductive medicine 606 $aEndocrinology  606 $aCell biology 606 $aReproductive Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H56002 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aReproductive medicine. 615 0$aEndocrinology . 615 0$aCell biology. 615 14$aReproductive Medicine. 615 24$aEndocrinology. 615 24$aCell Biology. 676 $a615.366 700 $aSmith$b Lee B$4aut$4http://id.loc.gov/vocabulary/relators/aut$01057958 702 $aMitchell$b Rod T$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMcEwan$b Iain J$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910437837103321 996 $aTestosterone: From Basic Research to Clinical Applications$92495886 997 $aUNINA