LEADER 04290nam 22008655 450 001 9910437837103321 005 20251002032654.0 010 $a9781461489788$b(electronic bk.) 010 $a1461489784$b(electronic bk.) 024 7 $a10.1007/978-1-4614-8978-8 035 $a(CKB)3710000000024311 035 $a(EBL)1466420 035 $a(OCoLC)861080701 035 $a(SSID)ssj0001049055 035 $a(PQKBManifestationID)11599470 035 $a(PQKBTitleCode)TC0001049055 035 $a(PQKBWorkID)11015082 035 $a(PQKB)11782147 035 $a(DE-He213)978-1-4614-8978-8 035 $a(MiAaPQ)EBC1466420 035 $a(PPN)176100202 035 $a(EXLCZ)993710000000024311 100 $a20131001d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTestosterone: From Basic Research to Clinical Applications /$fby Lee B. Smith, Rod T. Mitchell, Iain J. McEwan 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2013. 215 $a1 online resource (78 p.) $cillustrations (some color) 225 1 $aSpringerBriefs in Reproductive Biology,$x2194-4253 300 $aDescription based upon print version of record. 311 08$a1-4614-8977-6 320 $aIncludes bibliographical references. 327 $aHistory of Masculinization -- Recent Understanding of Masculinization -- Where Does Testosterone Come from and How Does It Act? -- Androgen Receptor Signaling in the Testis -- Androgen Signaling in Other Body Systems -- Manipulating Androgens for Therapy. 330 $aThis volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit. 410 0$aSpringerBriefs in Reproductive Biology,$x2194-4253 606 $aTestosterone 606 $aEndocrinology 606 $aCytology 606 $aTestosterone$3(DNLM)D013739 606 $aTestosterone$xphysiology$3(DNLM)D013739Q000502 606 $aTestosterone$xtherapeutic use$3(DNLM)D013739Q000627 606 $aLeydig Cells$xmetabolism$3(DNLM)D007985Q000378 606 $aReceptors, Androgen$xphysiology$3(DNLM)D011944Q000502 606 $aAndrogens$xtherapeutic use$3(DNLM)D000728Q000627 606 $aTestosterone$2homoit$3https://homosaurus.org/v3/homoit0001362 606 $aReproductive Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/H56002 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 615 0$aTestosterone. 615 0$aEndocrinology. 615 0$aCytology. 615 12$aTestosterone 615 12$aTestosterone$xphysiology 615 22$aTestosterone$xtherapeutic use 615 22$aLeydig Cells$xmetabolism 615 22$aReceptors, Androgen$xphysiology 615 22$aAndrogens$xtherapeutic use 615 7$aTestosterone. 615 14$aReproductive Medicine. 615 24$aEndocrinology. 615 24$aCell Biology. 676 $a615.366 700 $aSmith$b Lee B$4aut$4http://id.loc.gov/vocabulary/relators/aut$01057958 702 $aMitchell$b Rod T$4aut$4http://id.loc.gov/vocabulary/relators/aut 702 $aMcEwan$b I. J$4aut$4http://id.loc.gov/vocabulary/relators/aut 801 0$bMiAaPQ 801 2$bNZ-WeVUL 906 $aBOOK 912 $a9910437837103321 996 $aTestosterone: From Basic Research to Clinical Applications$92495886 997 $aUNINA