LEADER 03937nam 2200565 a 450 001 9910437836303321 005 20200520144314.0 010 $a94-007-6621-1 024 7 $a10.1007/978-94-007-6621-1 035 $a(CKB)2670000000372401 035 $a(EBL)1317054 035 $a(SSID)ssj0000894491 035 $a(PQKBManifestationID)11515296 035 $a(PQKBTitleCode)TC0000894491 035 $a(PQKBWorkID)10839513 035 $a(PQKB)10170251 035 $a(DE-He213)978-94-007-6621-1 035 $a(MiAaPQ)EBC1317054 035 $a(PPN)170494993 035 $a(EXLCZ)992670000000372401 100 $a20130506d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aTranscriptional and translational regulation of stem cells /$fGary Hime 205 $a1st ed. 2013. 210 $aDordrecht [Germany] ;$aNew York $cSpringer$d2013 215 $a1 online resource (370 p.) 225 1 $aAdvances in experimental medicine and biology,$x0065-2598 ;$vv. 786 300 $aDescription based upon print version of record. 311 $a94-007-6620-3 320 $aIncludes bibliographical references and index. 327 $apt. 1. Model stem cell systems -- pt. 2. Model stem cell systems -- pt. 3. Molecular families implicated in stem cell regulation. 330 $aStem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury.  In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced.  Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of  differentiation could disrupt tissue homeostasis or  repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and  Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators. This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researcher. 410 0$aAdvances in experimental medicine and biology ;$vv. 786. 606 $aStem cells 606 $aCells$xGrowth$xRegulation 615 0$aStem cells. 615 0$aCells$xGrowth$xRegulation. 676 $a616.027 700 $aHime$b Gary$01761250 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437836303321 996 $aTranscriptional and translational regulation of stem cells$94200577 997 $aUNINA