LEADER 04896nam 22007095 450 001 9910437835503321 005 20251117074508.0 010 $a3-7091-1428-4 024 7 $a10.1007/978-3-7091-1428-5 035 $a(CKB)3710000000088170 035 $a(EBL)1698390 035 $a(OCoLC)881161794 035 $a(SSID)ssj0001175009 035 $a(PQKBManifestationID)11687966 035 $a(PQKBTitleCode)TC0001175009 035 $a(PQKBWorkID)11116013 035 $a(PQKB)11262750 035 $a(DE-He213)978-3-7091-1428-5 035 $a(MiAaPQ)EBC1698390 035 $a(PPN)176747591 035 $a(EXLCZ)993710000000088170 100 $a20140210d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAngiogenesis and Vascularisation $eCellular and Molecular Mechanisms in Health and Diseases /$fedited by Józef Dulak, Alicja Józkowicz, Agnieszka ?oboda 205 $a1st ed. 2013. 210 1$aVienna :$cSpringer Vienna :$cImprint: Springer,$d2013. 215 $a1 online resource (414 p.) 300 $aDescription based upon print version of record. 311 08$a3-7091-1427-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCells and mediators:  Endothelial cell origin, differentiation, heterogeneity and function -- Developmental and pathological lymphangiogenesis -- Vascular resident endothelial side population cells -- Multiple role of proteases in angiogenesis -- Serpins in angiogenesis -- Molecular mechanisms: Endothelial transcriptional networks in the control of angiogenesis: the ETS factor -- Insights into roles of immediate-early genes in angiogenesis -- Molecular mechanisms of hypoxia-regulated angiogenesis -- MicroRNA Regulation of Angiogenesis -- Nrf2 transcription factor and heme oxygenase-1 as modulators of vascular injury and angiogenesis -- Metabolism of methylarginines and angiogenesis -- The Vasohibin Family: Novel Regulators of Angiogenesis -- Diseases and Therapy: Hypoxia-induced pathological angiogenesis in zebrafish -- Tumor angiogenesis: Fishing for screening models -- Vascular complications in diabetes -- Angiogenesis in rheumatoid arthritis -- Angiogenic signaling and structural abnormalities in tumors -- Endothelium in pathologic angiogenesis and angiogenesis-mediated therapies. 330 $aThe book presents  the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis.  The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed ? aggravated or impaired ? vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis. 606 $aImmunology 606 $aCancer$xResearch 606 $aCytology 606 $aOncology 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aImmunology. 615 0$aCancer$xResearch. 615 0$aCytology. 615 0$aOncology. 615 14$aImmunology. 615 24$aCancer Research. 615 24$aCell Biology. 615 24$aOncology. 676 $a612.1 676 $a612.1/3 676 $a612.13 702 $aDulak$b Jo?zef$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aJo?zkowicz$b Alicja$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $a?oboda$b Agnieszka$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437835503321 996 $aAngiogenesis and Vascularisation$92513713 997 $aUNINA