LEADER 03419nam  2200601 a 450 
001 9910437835403321
005 20200520144314.0
010   $a1-283-93490-6
010   $a3-642-27928-7
024 7 $a10.1007/978-3-642-27928-7
035   $a(CKB)2670000000317328
035   $a(EBL)1082435
035   $a(OCoLC)823388540
035   $a(SSID)ssj0000864732
035   $a(PQKBManifestationID)11942009
035   $a(PQKBTitleCode)TC0000864732
035   $a(PQKBWorkID)10837288
035   $a(PQKB)10327395
035   $a(DE-He213)978-3-642-27928-7
035   $a(MiAaPQ)EBC1082435
035   $a(PPN)168311208
035   $a(EXLCZ)992670000000317328
100   $a20121107d2013      uy         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 00$aProtein quality control in neurodegenerative diseases /$fRichard I. Morimoto, Yves Christen, editors
205   $a1st ed. 2013.
210   $aNew York $cSpringer$d2013
215   $a1 online resource (144 p.)
225  0$aResearch and perspectives in Alzheimer's disease,$x0945-6066
300   $aDescription based upon print version of record.
311   $a3-642-44706-6 
311   $a3-642-27927-9 
320   $aIncludes bibliographical references and index.
327   $aThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.
330   $aThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
410  0$aResearch and Perspectives in Alzheimer's Disease,$x0945-6066
606   $aNervous system$xDegeneration
615  0$aNervous system$xDegeneration.
676   $a616.8
676   $a616.80471
701   $aMorimoto$b Richard I$01760051
701   $aChristen$b Yves$0155886
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910437835403321
996   $aProtein quality control in neurodegenerative diseases$94198831
997   $aUNINA