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010   $a1-283-93490-6
010   $a3-642-27928-7
024 7 $a10.1007/978-3-642-27928-7
035   $a(CKB)2670000000317328
035   $a(EBL)1082435
035   $a(OCoLC)823388540
035   $a(SSID)ssj0000864732
035   $a(PQKBManifestationID)11942009
035   $a(PQKBTitleCode)TC0000864732
035   $a(PQKBWorkID)10837288
035   $a(PQKB)10327395
035   $a(DE-He213)978-3-642-27928-7
035   $a(MiAaPQ)EBC1082435
035   $a(PPN)168311208
035   $a(EXLCZ)992670000000317328
100   $a20121212d2013      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aProtein Quality Control in Neurodegenerative Diseases /$fedited by Richard I. Morimoto, Yves Christen
205   $a1st ed. 2013.
210  1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013.
215   $a1 online resource (144 p.)
225 1 $aResearch and Perspectives in Alzheimer's Disease,$x0945-6066
300   $aDescription based upon print version of record.
311   $a3-642-44706-6 
311   $a3-642-27927-9 
320   $aIncludes bibliographical references and index.
327   $aThe Regulation and Function of the Heat Shock Response by Eric Guisbert and Richard I. Morimoto -- The Endoplasmic Reticulum Unfolded Protein Response and Neurodegeneration by David Ron -- Proteostasis and the aging pathways by Ian Nicastro and Andrew Dillin -- The Membrane Sources of Macroautophagy by Daniel J. Klionsky, Melinda A. Lynch-Day, Jiefei Geng, and Wei-Lien Yen -- Selective Autophagy in Cellular Quality Control by Susmita Kaushik and Ana Maria Cuervo -- Quality Control of Proteins and Organelles by Autophagy by Noboru Mizushima -- The Role of the Co-Chaperone BAG3 in Selective Macroautophagy: Implications for Aging and Disease by Christian Behl -- Predicting Fates in Models of Neurodegenerative Disease: Longitudinal Measures of Protein Homeostasis in Live Neurons by Steven Finkbeiner -- Therapeutic Potential of Longevity Modulators as Neuroprotective Targets in Neurodegenerative Disease by Rafael Vazquez-Manrique, Cendrine Tourette and Christian Neri -- Subject code.
330   $aThe health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.
410  0$aResearch and Perspectives in Alzheimer's Disease,$x0945-6066
606   $aNeurosciences
606   $aNeurochemistry
606   $aMolecular biology
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aNeurochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/B18010
606   $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X
615  0$aNeurosciences.
615  0$aNeurochemistry.
615  0$aMolecular biology.
615 14$aNeurosciences.
615 24$aNeurochemistry.
615 24$aMolecular Medicine.
676   $a616.8
676   $a616.80471
702   $aMorimoto$b Richard I$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aChristen$b Yves$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910437835403321
996   $aProtein Quality Control in Neurodegenerative Diseases$92513712
997   $aUNINA