LEADER 04505nam 2200649 a 450 001 9910437834903321 005 20200520144314.0 010 $a1-283-93368-3 010 $a1-4614-4756-9 024 7 $a10.1007/978-1-4614-4756-6 035 $a(CKB)2670000000316631 035 $a(EBL)1106451 035 $a(OCoLC)823722434 035 $a(SSID)ssj0000811865 035 $a(PQKBManifestationID)11512376 035 $a(PQKBTitleCode)TC0000811865 035 $a(PQKBWorkID)10859219 035 $a(PQKB)10562064 035 $a(DE-He213)978-1-4614-4756-6 035 $a(MiAaPQ)EBC1106451 035 $a(PPN)168301121 035 $a(EXLCZ)992670000000316631 100 $a20121227d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSodium calcium exchange $ea growing spectrum of pathophysiological implications : proceedings of the 6th International Conference on Sodium Calcium Exchange /$fLucio Annunziato, editor 205 $a1st ed. 2013. 210 $aNew York $cSpringer$d2013 215 $a1 online resource (456 p.) 225 0$aAdvances in experimental medicine and biology 300 $aDescription based upon print version of record. 311 $a1-4614-4755-0 320 $aIncludes bibliographical references and indexes. 327 $apt. I. Historical perspective -- pt. II. Structural and functional aspects of NCX -- pt. III. Structural and functional aspects of NCKX -- pt. IV. Genetic and epigenetic regulation -- pt. V. Regulatory mechanisms of NCX -- pt. VI. Subcellular localization and function of NCX in Ca[superscript 2+]-storing organelles and mitochondria -- pt. VII. NCX in neurodegenerative diseases -- pt. VIII. Emerging role of NCX activity in immune and glial cells -- pt. IX. NCX in the heart and vascular smooth muscle -- pt. X. NCX role in hypertension, heart failure, ischemia-reperfusion, arrhythmias and diabetes -- pt. XI. NCX partners in ionic homeostasis : ASIC, NMDA, NHE and TRPC. 330 $aThis book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract. The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.   Lucio Annunziato is Professor of Pharmacology and chairman of the Department of Neuroscience in the School of Medicine at the ?Federico II? University of Naples, Italy. He is coordinator of the University?s Neuroscience Ph.D. program. He is also past-president of the Italian Society for Neuroscience. Dr. Annunziato has authored more that 190 full papers in peer reviewed international journals in the field of neuroscience and molecular pharmacology of plasmamembrane transporters and ionic channels involved in the pathophysiology of stroke and other neurodegenerative diseases. . 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v961 606 $aSodium channels$vCongresses 606 $aCalcium channels$vCongresses 606 $aSodium cotransport systems$vCongresses 615 0$aSodium channels 615 0$aCalcium channels 615 0$aSodium cotransport systems 676 $a500 676 $a591.19/214 676 $a612.01524 701 $aAnnunziato$b Lucio$0560530 712 12$aInternational Conference on Sodium-Calcium Exchange 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437834903321 996 $aSodium calcium exchange$94200801 997 $aUNINA