LEADER 03660nam 2200601 a 450 001 9910437834503321 005 20200520144314.0 010 $a1-283-93378-0 010 $a1-4614-4954-5 024 7 $a10.1007/978-1-4614-4954-6 035 $a(CKB)3400000000093724 035 $a(EBL)1081861 035 $a(OCoLC)822997139 035 $a(SSID)ssj0000810521 035 $a(PQKBManifestationID)11458773 035 $a(PQKBTitleCode)TC0000810521 035 $a(PQKBWorkID)10828581 035 $a(PQKB)11652947 035 $a(DE-He213)978-1-4614-4954-6 035 $a(MiAaPQ)EBC1081861 035 $a(PPN)168301652 035 $a(EXLCZ)993400000000093724 100 $a20121219d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiophysics of RNA folding /$fRick Russell, editor 205 $a1st ed. 2013. 210 $aDordrecht [Netherlands] ;$aNew York $cSpringer$d2013 215 $a1 online resource (237 p.) 225 1 $aBiophysics for the Life Sciences ;$v3 300 $aDescription based upon print version of record. 311 $a1-4899-8894-7 311 $a1-4614-4953-7 320 $aIncludes bibliographical references and index. 327 $aIntroduction -- Comparative Analysis of the Higher-order Structure of RNA -- Graph Applications to RNA Structure and Function -- Prediction and Coarse-Grained Modeling of RNA Structures -- RNA Folding Using Site-Directed Spin Labeling -- The RNA Recognition Motif and Messenger RNA -- Memory Effects in RNA folding dynamics revealed by single molecule fluorescence -- An integrated picture of HDV ribozyme catalysis -- Combining biochemical and structural information to model RNA-protein complex assembly -- Following RNA Folding From Local and Global Perspectives -- The Roles of Chaperones in RNA Folding. 330 $aStructured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins. This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding. 410 0$aBiophysics for the Life Sciences ;$v3 606 $aProtein folding 606 $aPeptides 615 0$aProtein folding. 615 0$aPeptides. 676 $a572.8 701 $aRussell$b Rick$01752247 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437834503321 996 $aBiophysics of RNA folding$94187509 997 $aUNINA