LEADER 05352nam 22006615 450 001 9910437833103321 005 20200630204911.0 010 $a1-283-91194-9 010 $a1-4614-5847-1 024 7 $a10.1007/978-1-4614-5847-0 035 $a(CKB)3390000000031579 035 $a(EBL)1082015 035 $a(OCoLC)821617798 035 $a(SSID)ssj0000810590 035 $a(PQKBManifestationID)11503835 035 $a(PQKBTitleCode)TC0000810590 035 $a(PQKBWorkID)10827401 035 $a(PQKB)10873981 035 $a(DE-He213)978-1-4614-5847-0 035 $a(MiAaPQ)EBC1082015 035 $a(PPN)168304058 035 $a(EXLCZ)993390000000031579 100 $a20121116d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aCell Death Signaling in Cancer Biology and Treatment$b[electronic resource] /$fedited by Daniel Johnson 205 $a1st ed. 2013. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Humana,$d2013. 215 $a1 online resource (411 p.) 225 1 $aCell Death in Biology and Diseases,$x2625-2902 300 $aDescription based upon print version of record. 311 $a1-4939-0107-9 311 $a1-4614-5846-3 320 $aincludes bibliographical references and index. 327 $aDefective Apoptosis Signaling in Cancer -- The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells -- Emerging Opportunities for Targeting the Tumor-Stroma Interactions for Increasing the Efficacy of Chemotherapy -- The Role of Autophagy in Drug Resistance and Potential for Therapeutic Targeting -- microRNAs in Cell Death and Cancer -- Targeting DNA Repair Pathways for Cancer Therapy -- Molecular Chaperones and How Addiction Matters in Cancer Therapy -- Sphingolipid Metabolism and Signaling as a Target for Cancer Treatment -- Leading Small Molecule Inhibitors of Anti-apoptotic Bcl-2 Family Members -- SMAC IAP Addiction in Cancer -- Harnessing Death Receptor Signaling for Cancer Treatment -- Proteasome Inhibition as a Novel Strategy for Cancer Treatment -- New Agents and Approaches for Targeting the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR Cell Survival Pathways -- Activation of Immune-Mediated Tumor Cell Death by Chemotherapy. 330 $aDefects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients.  Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies.  In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death.  Each chapter also highlights recent advances in the translation of basic research findings into clinical trials.  Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens.  The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes.  Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways.  Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities.  In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies. 410 0$aCell Death in Biology and Diseases,$x2625-2902 606 $aCell biology 606 $aApoptosis 606 $aCancer research 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 606 $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001 615 0$aCell biology. 615 0$aApoptosis. 615 0$aCancer research. 615 14$aCell Biology. 615 24$aApoptosis. 615 24$aCancer Research. 676 $a616.99406 702 $aJohnson$b Daniel$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910437833103321 996 $aCell Death Signaling in Cancer Biology and Treatment$92510098 997 $aUNINA