LEADER 04894nam 22009375 450 001 9910437832303321 005 20200706185252.0 010 $a3-642-43836-9 010 $a3-642-36340-7 024 7 $a10.1007/978-3-642-36340-5 035 $a(CKB)3460000000120384 035 $a(EBL)1697254 035 $a(OCoLC)829740636 035 $a(SSID)ssj0000879052 035 $a(PQKBManifestationID)11514906 035 $a(PQKBTitleCode)TC0000879052 035 $a(PQKBWorkID)10837777 035 $a(PQKB)10552260 035 $a(DE-He213)978-3-642-36340-5 035 $a(MiAaPQ)EBC1697254 035 $a(PPN)168330059 035 $a(EXLCZ)993460000000120384 100 $a20130228d2013 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aHost-Pathogen Interactions in Streptococcal Diseases$b[electronic resource] /$fedited by G Singh Chhatwal 205 $a1st ed. 2013. 210 1$aBerlin, Heidelberg :$cSpringer Berlin Heidelberg :$cImprint: Springer,$d2013. 215 $a1 online resource (258 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v368 300 $aDescription based upon print version of record. 311 $a1-306-70287-9 311 $a3-642-36339-3 320 $aIncludes bibliographical references. 327 $aGroup A Streptococcal Diseases and Their Global Burden -- Molecular Markers for the Study of Streptococcal Epidemiology -- Epidemiology and Pathogenicity of Zoonotic Streptococci -- Adherence and Invasion of Streptococci to Eukaryotic Cells and Their Role in Disease Pathogenesis -- Common Regulators of Virulence in Streptococci -- Host-Pathogen Interactions in Streptococcal Immune Sequelae -- Immunopathogenesis of Streptococcal Deep Tissue Infections -- Modulation of the Coagulation System During Severe Streptococcal Disease -- Group A Streptococcal Vaccine Candidates: Potential for the Development of a Human Vaccine -- Clinical Management of the Most Common Group A ?-Hemolytic Streptococcal Infections. 330 $aStreptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases. 410 0$aCurrent Topics in Microbiology and Immunology,$x0070-217X ;$v368 606 $aMedical microbiology 606 $aImmunology 606 $aVaccines 606 $aMolecular biology 606 $aPublic health 606 $aBacteriology 606 $aMedical Microbiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B16003 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aVaccine$3https://scigraph.springernature.com/ontologies/product-market-codes/B16010 606 $aMolecular Medicine$3https://scigraph.springernature.com/ontologies/product-market-codes/B1700X 606 $aPublic Health$3https://scigraph.springernature.com/ontologies/product-market-codes/H27002 606 $aBacteriology$3https://scigraph.springernature.com/ontologies/product-market-codes/L23012 615 0$aMedical microbiology. 615 0$aImmunology. 615 0$aVaccines. 615 0$aMolecular biology. 615 0$aPublic health. 615 0$aBacteriology. 615 14$aMedical Microbiology. 615 24$aImmunology. 615 24$aVaccine. 615 24$aMolecular Medicine. 615 24$aPublic Health. 615 24$aBacteriology. 676 $a579.3 676 $a610 676 $a611.01816 676 $a613 676 $a614 676 $a615.372 676 $a616.079 676 $a616.9/298 676 $a616.9041 702 $aChhatwal$b G Singh$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910437832303321 996 $aHost-Pathogen Interactions in Streptococcal Diseases$92546211 997 $aUNINA